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Literature summary extracted from

  • Wendroth, S.; Seitz, H.U.
    Characterization and localization of progesterone 5alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH) (1990), Biochem. J., 266, 41-46.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.22 2-mercaptoethanol 3fold activity at 1 mM Digitalis lanata
1.3.1.22 dithiothreitol 3fold activity at 1 mM Digitalis lanata

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 Ca2+
-
Digitalis lanata
1.3.1.22 Co2+
-
Digitalis lanata
1.3.1.22 Zn2+
-
Digitalis lanata

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.03
-
progesterone
-
Digitalis lanata
1.3.1.22 0.13
-
NADPH
-
Digitalis lanata

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 endoplasmic reticulum
-
Digitalis lanata 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.22 EDTA stimulatory at concentration 2 mM Digitalis lanata
1.3.1.22 Mg2+ stimulatory at concentration 1 mM Digitalis lanata
1.3.1.22 additional information not dependent on divalent cation Digitalis lanata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+ Digitalis lanata biosynthesis of cardenolides 5alpha-pregnan-3-20-dione + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Digitalis lanata
-
floxglove
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 cell suspension culture
-
Digitalis lanata
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.22 0.34
-
with NADPH Digitalis lanata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+
-
Digitalis lanata 5alpha-pregnan-3-20-dione + NADP+
-
?
1.3.1.22 progesterone + NADPH + H+ biosynthesis of cardenolides Digitalis lanata 5alpha-pregnan-3-20-dione + NADP+
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.22 40
-
-
Digitalis lanata

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.3.1.22 additional information
-
-
Digitalis lanata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 7
-
-
Digitalis lanata

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.22 6.3 7.5
-
Digitalis lanata

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH cannot be replaced by NADH Digitalis lanata