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Literature summary extracted from

  • Paiva, A.M.; Vanderwall, D.E.; Blanchard, J.S.; Kozarich, J.W.; Williamson, J.M.; Kelly, T.M.
    Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis (2001), Biochim. Biophys. Acta, 1545, 67-77.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.17.1.8 medicine
-
 Escherichia coli
1.17.1.8 medicine potential drug target in therapy of tuberculosis caused by resistent strains of Mycobacterium tuberculosis, molecular modeling for identification of potential inhibitors Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.1.8 dapB gene, expression in Escherichia coli Mycobacterium tuberculosis
1.17.1.8 dapB gene, overexpression from plasmid in Escherichia coli Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.8 2,6-pyridinedicarboxylic acid
-
 Escherichia coli
1.17.1.8 2,6-pyridinedicarboxylic acid
-
 Mycobacterium tuberculosis
1.17.1.8 additional information investigation of inhibitory potential of diverse heterocyclic and aromatic compounds, overview Mycobacterium tuberculosis
1.17.1.8 sulfonamide derivatives
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Escherichia coli
-
 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Mycobacterium tuberculosis essentially involved in cell wall synthesis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.8 Escherichia coli P04036
-
-
1.17.1.8 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.8 overexpression in Escherichia coli from plasmid Escherichia coli
1.17.1.8 recombinant enzyme expressed in Escherichia coli Mycobacterium tuberculosis

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ binding mechanism of diverse inhibitors Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H
-
 Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H
-
 Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H essentially involved in cell wall synthesis Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.1.8 DHDP reductase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.8 NADH
-
 Escherichia coli
1.17.1.8 NADPH
-
 Mycobacterium tuberculosis
1.17.1.8 NADPH
-
 Escherichia coli