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Literature summary extracted from

  • Ahmad, S.; Jensen, R.A.
    The prephenate dehydrogenase component of the bifunctional T-protein in enteric bacteria can utilize L-arogenate (1987), FEBS Lett., 216, 133-139.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.12 L-tyrosine
-
 Escherichia coli
1.3.1.12 L-tyrosine
-
 Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.12 prephenate + NAD+ Escherichia coli biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ Klebsiella pneumoniae biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.12 Escherichia coli
-
 K12
-
1.3.1.12 Escherichia coli
-
 strains B and W
-
1.3.1.12 Klebsiella pneumoniae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.12 chorismate mutase-prephenate dehydrogenase bifunctional enzyme Escherichia coli
1.3.1.12 chorismate mutase-prephenate dehydrogenase bifunctional enzyme Klebsiella pneumoniae
1.3.1.12 partial Escherichia coli
1.3.1.12 partial Klebsiella pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.12 L-arogenate + NAD+
-
 Escherichia coli L-tyrosine + NADH + CO2
-
 ?
1.3.1.12 L-arogenate + NAD+
-
 Klebsiella pneumoniae L-tyrosine + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+
-
 Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+
-
 Klebsiella pneumoniae 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Klebsiella pneumoniae 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.12 bifunctional T-protein
-
 Escherichia coli
1.3.1.12 bifunctional T-protein
-
 Klebsiella pneumoniae
1.3.1.12 chorismate mutase-prephenate dehydrogenase bifunctional enzyme complex with EC 5.4.99.5 Escherichia coli
1.3.1.12 chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme
-
 Escherichia coli
1.3.1.12 chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme
-
 Klebsiella pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.12 additional information NADP+ cannot substitute for NAD+ Escherichia coli
1.3.1.12 additional information NADP+ cannot substitute for NAD+ Klebsiella pneumoniae
1.3.1.12 NAD+
-
 Escherichia coli
1.3.1.12 NAD+
-
 Klebsiella pneumoniae