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Literature summary extracted from

  • Berry, A.; Jensen, R.A.; Hendry, A.T.
    Enzymic arrangement and allosteric regulation of the aromatic amino acid pathway in Neisseria gonorrhoeae (1987), Arch. Microbiol., 149, 87-94.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.12 4-hydroxyphenylpyruvate
-
 Neisseria gonorrhoeae
1.3.1.12 L-tyrosine not inhibiting Neisseria gonorrhoeae
1.3.1.43 4-hydroxyphenylpyruvate
-
 Neisseria gonorrhoeae
1.3.1.43 L-tyrosine no inhibition Neisseria gonorrhoeae
1.3.1.43 phenylpyruvate
-
 Neisseria gonorrhoeae
1.3.1.43 prephenate no inhibition Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.12 prephenate + NAD+ Neisseria gonorrhoeae biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.43 L-arogenate + NAD+ Neisseria gonorrhoeae
-
 L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.12 Neisseria gonorrhoeae
-
-
-
1.3.1.43 Neisseria gonorrhoeae
-
 ATCC 27630 and isolated HGH 154
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.12 additional information
-
-
 Neisseria gonorrhoeae
1.3.1.43 0.0017
-
 ATCC 27360 Neisseria gonorrhoeae
1.3.1.43 0.0058
-
 HGH 154 Neisseria gonorrhoeae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.12 prephenate + NAD+
-
 Neisseria gonorrhoeae 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.12 prephenate + NAD+ biosynthesis of L-tyrosine Neisseria gonorrhoeae 4-hydroxyphenylpyruvate + NADH + CO2
-
 ?
1.3.1.43 L-arogenate + NAD(P)+
-
 Neisseria gonorrhoeae L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.43 L-arogenate + NAD+
-
 Neisseria gonorrhoeae L-tyrosine + NADH + CO2
-
 ?
1.3.1.43 prephenate + NAD(P)+
-
 Neisseria gonorrhoeae ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.12 additional information NADP+ cannot substitute for NAD+ Neisseria gonorrhoeae
1.3.1.12 NAD+
-
 Neisseria gonorrhoeae
1.3.1.43 NAD+
-
 Neisseria gonorrhoeae