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Literature summary extracted from

  • Sugihara, K.; Katsuma, Y.; Tanaka, C.; Kitamura, S.
    Purification and some properties of hamster liver aldehyde oxidase (1999), Biol. Pharm. Bull., 22, 1246-1248.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 chlorpromazine
-
 Cavia porcellus
1.2.3.1 chlorpromazine 94% inhibition at 0.1 mM Mesocricetus auratus
1.2.3.1 CuSO4 85% inhibition at 0.1 mM Mesocricetus auratus
1.2.3.1 dicoumarol
-
 Cavia porcellus
1.2.3.1 dicoumarol 43% inhibition at 0.1 mM Mesocricetus auratus
1.2.3.1 KCN
-
 Cavia porcellus
1.2.3.1 KCN 95% inhibition at 1 mM Mesocricetus auratus
1.2.3.1 KCN
-
 Oryctolagus cuniculus
1.2.3.1 menadione
-
 Cavia porcellus
1.2.3.1 menadione 91.5% inhibition at 0.01 mM Mesocricetus auratus
1.2.3.1 menadione
-
 Oryctolagus cuniculus
1.2.3.1 p-chloromercuribenzoic acid
-
 Cavia porcellus
1.2.3.1 p-chloromercuribenzoic acid 96% inhibition at 0.1 mM Mesocricetus auratus
1.2.3.1 Quinacrine 74% inhibition at 0.1 mM Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.3.1 0.0044
-
 2-hydroxypyrimidine
-
 Mesocricetus auratus
1.2.3.1 0.019
-
 benzaldehyde
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.3.1 cytosol
-
 Cavia porcellus 5829
-
1.2.3.1 cytosol
-
 Oryctolagus cuniculus 5829
-
1.2.3.1 cytosol
-
 Mesocricetus auratus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.3.1 Fe2+
-
 Cavia porcellus
1.2.3.1 Fe2+
-
 Oryctolagus cuniculus
1.2.3.1 Fe2+
-
 Mesocricetus auratus
1.2.3.1 Mo5+
-
 Cavia porcellus
1.2.3.1 Mo5+
-
 Oryctolagus cuniculus
1.2.3.1 Mo5+
-
 Mesocricetus auratus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.3.1 144800
-
 alpha2, 2 * 144800, SDS-PAGE Mesocricetus auratus
1.2.3.1 288000
-
 gel filtration Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.3.1 additional information Mesocricetus auratus enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Cavia porcellus
-
-
-
1.2.3.1 Mesocricetus auratus
-
-
-
1.2.3.1 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.3.1
-
 Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Cavia porcellus
-
1.2.3.1 liver
-
 Oryctolagus cuniculus
-
1.2.3.1 liver
-
 Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.3.1 0.77
-
-
 Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 2-hydroxypyrimidine + H2O + O2
-
 Cavia porcellus uracil + H2O2
-
 ?
1.2.3.1 2-hydroxypyrimidine + H2O + O2
-
 Oryctolagus cuniculus uracil + H2O2
-
 ?
1.2.3.1 2-hydroxypyrimidine + H2O + O2
-
 Mesocricetus auratus uracil + H2O2
-
 ?
1.2.3.1 benzaldehyde + H2O + O2
-
 Cavia porcellus benzoic acid + H2O2
-
 ?
1.2.3.1 benzaldehyde + H2O + O2
-
 Oryctolagus cuniculus benzoic acid + H2O2
-
 ?
1.2.3.1 benzaldehyde + H2O + O2
-
 Mesocricetus auratus benzoic acid + H2O2
-
 ?
1.2.3.1 additional information enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants Mesocricetus auratus ?
-
 ?
1.2.3.1 N1-methylnicotinamide + H2O + O2
-
 Cavia porcellus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?
1.2.3.1 N1-methylnicotinamide + H2O + O2
-
 Oryctolagus cuniculus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?
1.2.3.1 N1-methylnicotinamide + H2O + O2
-
 Mesocricetus auratus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.3.1 dimer alpha2, 2 * 144800, SDS-PAGE Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.3.1 FAD
-
 Cavia porcellus
1.2.3.1 FAD
-
 Oryctolagus cuniculus
1.2.3.1 FAD
-
 Mesocricetus auratus