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Literature summary extracted from

  • Nishizuka, Y.; Ichiyama, A.; Hayaishi, O.
    alpha-Aminomuconic epsilon-semialdehyde dehydrogenase (cat liver) (1970), Methods Enzymol., 17A, 476-483.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.32 Co2+ 0.2 mM, almost complete inhibition Felis catus
1.2.1.32 Cu2+ 0.2 mM, almost complete inhibition Felis catus
1.2.1.32 Hg2+ 0.2 mM, almost complete inhibition Felis catus
1.2.1.32 Ni2+ 0.2 mM, almost complete inhibition Felis catus
1.2.1.32 p-chloromercuribenzoate 100% inhibition at 20 mM, 52% inhibition at 0.01 mM, 1 mM cysteine reverses inhibition completely Felis catus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.32 0.016
-
 2-hydroxymuconate-6-semialdehyde
-
 Felis catus
1.2.1.32 0.019
-
 NAD+
-
 Felis catus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.32 Felis catus
-
-
-
1.2.1.32 Pseudomonas sp.
-
 o-cresol adapted cells
-
1.2.1.32 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.32 partial Rattus norvegicus
1.2.1.32 partial Felis catus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.32 liver
-
 Rattus norvegicus
-
1.2.1.32 liver
-
 Felis catus
-

Storage Stability

EC Number Storage Stability Organism
1.2.1.32 -10°C, 1 week, 50% loss of activity Felis catus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.32 2-aminomuconate-6-semialdehyde + NAD+ + H2O
-
 Felis catus 2-aminomuconate + NADH
-
 ?
1.2.1.32 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate + NAD+ + H2O synonym 5-methyl-2-hydroxymuconic-6-semialdehyde Felis catus 2-hydroxy-5-methylmuconate + NADH
-
 ?
1.2.1.32 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O
-
 Pseudomonas sp. 2-hydroxymuconate + NADH
-
 ?
1.2.1.32 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O
-
 Felis catus 2-hydroxymuconate + NADH
-
 ?
1.2.1.32 acetaldehyde + NAD+ + H2O low activity Felis catus acetate + NADH + H+
-
 ?
1.2.1.32 formaldehyde + NAD+ + H2O
-
 Felis catus formate + NADH
-
 ?
1.2.1.32 n-butanal + NAD+ + H2O
-
 Felis catus n-butanoate + NADH + H+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.32 25
-
 assay at Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.32 7.5 8
-
 Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.32 NAD+
-
 Pseudomonas sp.
1.2.1.32 NAD+ specific for, not replaceable by NADP+ Felis catus