EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.11 | H2CO3 | enhances activity 4 or 5 times in both directions | Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.11 | cysteine | in the reverse reaction | Saccharomyces cerevisiae | |
1.2.1.11 | homocysteine | in the reverse reaction | Saccharomyces cerevisiae | |
1.2.1.11 | L-methionine | - |
Saccharomyces cerevisiae | |
1.2.1.11 | L-threonine | - |
Saccharomyces cerevisiae | |
1.2.1.11 | additional information | no feed-back inhibition by threonine or methionine | Saccharomyces cerevisiae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.11 | 1.4 | - |
phosphate | - |
Saccharomyces cerevisiae |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.11 | 140000 | - |
gel filtration | Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.11 | L-4-aspartyl phosphate + NADPH | Saccharomyces cerevisiae | synthesis of threonine | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
1.2.1.11 | L-4-aspartyl phosphate + NADPH | Saccharomyces cerevisiae | synthesis of methionine | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.11 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.11 | using ammonium sulfate precipitation and column chromatography on Sephadex G-200, DEAE-cellulose and hydroxylapatite | Saccharomyces cerevisiae |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.11 | additional information | - |
- |
Saccharomyces cerevisiae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.11 | L-4-aspartyl phosphate + NADPH | synthesis of threonine | Saccharomyces cerevisiae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
1.2.1.11 | L-4-aspartyl phosphate + NADPH | synthesis of methionine | Saccharomyces cerevisiae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
1.2.1.11 | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Saccharomyces cerevisiae | L-4-aspartyl phosphate + NADPH | - |
r |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.11 | 8.5 | - |
in both directions | Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.11 | NADP+ | - |
Saccharomyces cerevisiae | |
1.2.1.11 | NADPH | - |
Saccharomyces cerevisiae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.11 | 10 | - |
homocysteine | - |
Saccharomyces cerevisiae |