Literature summary extracted from

Cloutier, M.; Fleury, A.; Courtemanche, J.; Ducharme, L.; Mason, J.I.; Lehoux, J.G.
Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis (1997), DNA Cell Biol., 16, 357-368.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.14.19	expression in Cos-1 cells	Mesocricetus auratus
1.14.14.32	full length cDNA clone encoding cytochrome P450C17 expressed in COS 1 cells	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.19	pregnenolone + AH2 + O2	Mesocricetus auratus	-	17alpha-hydroxypregnenolone + A + H2O	product eliminates at C20,21 acetate to yield dehydroepiandrosterone	?
1.14.14.19	progesterone + [reduced NADPH-hemoprotein reductase] + O2	Mesocricetus auratus	-	17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O	product eliminates at C20,21 acetate to yield androstenedione	?
1.14.14.32	additional information	Mesocricetus auratus	adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.19	Mesocricetus auratus	-	-	-
1.14.14.32	Mesocricetus auratus	-	Golden Syrian hamster	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.19	adrenal gland	-	Mesocricetus auratus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.19	pregnenolone + AH2 + O2	-	Mesocricetus auratus	17alpha-hydroxypregnenolone + A + H2O	product eliminates at C20,21 acetate to yield dehydroepiandrosterone	?
1.14.14.19	progesterone + [reduced NADPH-hemoprotein reductase] + O2	-	Mesocricetus auratus	17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O	product eliminates at C20,21 acetate to yield androstenedione	?
1.14.14.32	17alpha-Hydroxypregnenolone	-	Mesocricetus auratus	Dehydroepiandrosterone + acetaldehyde	DHEA	?
1.14.14.32	17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2	-	Mesocricetus auratus	androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O	androstenedione	?
1.14.14.32	additional information	adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA	Mesocricetus auratus	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.19	P450c17	-	Mesocricetus auratus

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Release 2023.1 (January 2023)