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Literature summary extracted from

  • Dang, Y.; Xia, C.; Brown, O.R.
    Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway (1998), Free Radic. Biol. Med., 25, 1033-1043.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.10.3.5 medicine enzyme activity increases in the brains of Huntington disease victims Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.3.5
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.3.5 0.014
-
3-Hydroxyanthranilate air used as source of oxygen Rattus norvegicus
1.10.3.5 0.05
-
3-Hydroxyanthranilate
-
Rattus norvegicus
1.10.3.5 0.26
-
O2
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.5 Fe2+ required for activation Rattus norvegicus
1.10.3.5 Fe2+ required for activation Bos taurus
1.10.3.5 Fe2+ required for activation Felis catus
1.10.3.5 Fe2+ required for activation Oncorhynchus mykiss

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.5 Bos taurus
-
beef, cow, calf
-
1.10.3.5 Felis catus
-
-
-
1.10.3.5 Homo sapiens
-
human
-
1.10.3.5 Oncorhynchus mykiss
-
rainbow trout
-
1.10.3.5 Rattus norvegicus
-
Sprague-Dawley
-
1.10.3.5 Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.5
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.3.5 brain
-
Homo sapiens
-
1.10.3.5 brain
-
Rattus norvegicus
-
1.10.3.5 brain
-
Felis catus
-
1.10.3.5 kidney
-
Rattus norvegicus
-
1.10.3.5 kidney
-
Bos taurus
-
1.10.3.5 liver
-
Rattus norvegicus
-
1.10.3.5 liver
-
Bos taurus
-
1.10.3.5 liver
-
Felis catus
-
1.10.3.5 liver
-
Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.10.3.5 0.22
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Homo sapiens 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Rattus norvegicus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Bos taurus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Felis catus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Oncorhynchus mykiss 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
Rattus norvegicus Sprague-Dawley 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.5 3-hydroxyanthranilic acid dioxygenase
-
Homo sapiens
1.10.3.5 3HAO
-
Rattus norvegicus
1.10.3.5 3HAO
-
Bos taurus
1.10.3.5 3HAO
-
Felis catus
1.10.3.5 3HAO
-
Oncorhynchus mykiss

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.10.3.5 31
-
-
Rattus norvegicus