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Literature summary extracted from

  • Ferjancic-Biagini, A.; Dupuis, L.; De Caro, J.; Puigserver, A.
    Inhibitory effects of anions and active site amino acid sequence of chicken liver L-2-hydroxyacid oxidase A, a member of the FMN-dependent alpha-hydroxy acid oxidizing enzyme family (1998), Biochimie, 80, 1047-1054.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.3.15 acetate mixed-type non-competitive inhibition Gallus gallus
1.1.3.15 caproate mixed-type non-competitive inhibition Gallus gallus
1.1.3.15 oxalate mixed-type non-competitive inhibition, increasing inhibitory effects as the number of carbons in aliphatic chains decreases Gallus gallus
1.1.3.15 oxamate mixed-type non-competitive inhibition Gallus gallus
1.1.3.15 propionate mixed-type non-competitive inhibition Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.3.15 1.82
-
 L-2-hydroxy-4-methylthiobutanoic acid
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.3.15 peroxisome
-
 Gallus gallus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.15 L-2-hydroxy-4-methylthiobutanoic acid + O2 Gallus gallus oxidative decarboxylation 3-(methylthio)propanoate + HCO3-
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.15 Gallus gallus
-
 chicken
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.15 kidney
-
 Gallus gallus
-
1.1.3.15 liver isoenzyme L-2-hydroxyacid oxidase A Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.15 L-2-hydroxy-4-methylthiobutanoic acid + O2 oxidative decarboxylation Gallus gallus 3-(methylthio)propanoate + HCO3-
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.3.15 L-2-hydroxyacid oxidase A
-
 Gallus gallus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.3.15 0.74
-
 L-2-hydroxy-4-methylthiobutanoic acid
-
 Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.3.15 FMN
-
 Gallus gallus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.3.15 3
-
 caproate
-
 Gallus gallus
1.1.3.15 5
-
 oxalate
-
 Gallus gallus
1.1.3.15 126
-
 propionate
-
 Gallus gallus
1.1.3.15 171
-
 oxamate
-
 Gallus gallus
1.1.3.15 494
-
 acetate decreasing values as the number of carbons in the alkyl side chain increases from 1 to 2 and to 5 Gallus gallus