EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.50 | 17alpha-methyltestosterone | competitive inhibition | Bos taurus | |
1.1.1.50 | 5,5'-dithiobis(2-nitrobenzoic acid) | - |
Bos taurus | |
1.1.1.50 | ethacrynate | - |
Bos taurus | |
1.1.1.50 | ethynylestradiol | competitive inhibition | Bos taurus | |
1.1.1.50 | indomethacin | - |
Bos taurus | |
1.1.1.50 | megestrol | competitive inhibition | Bos taurus | |
1.1.1.50 | sulfhydryl oxidizing reagents | - |
Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.50 | cytosol | - |
Bos taurus | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.50 | 35000 | - |
gel filtration | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.50 | additional information | Bos taurus | broad substrate range | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.50 | Bos taurus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.50 | - |
Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.50 | 0.15 | - |
purified enzyme | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.50 | 3alpha-hydroxy-5beta-androstan-17-one + NADP+ | - |
Bos taurus | 5beta-androstan-3,17-dione + NADPH | - |
r | |
1.1.1.50 | 5alpha-androstan-3,17-dione + NADPH + H+ | - |
Bos taurus | 3alpha-hydroxy-5alpha-androstan-17-one + NADP+ | - |
r | |
1.1.1.50 | 5beta-androstan-3,17-dione + NADPH | - |
Bos taurus | 5beta-androstan-3alpha,17alpha-diol + NADP+ | - |
r | |
1.1.1.50 | 5beta-androstan-3alpha-ol-17-one + NADPH | - |
Bos taurus | 5beta-androstan-3alpha,17alpha-diol + NADP+ | - |
r | |
1.1.1.50 | 9,10-phenanthrenequinone + NADPH | - |
Bos taurus | ? | - |
? | |
1.1.1.50 | androsterone + NAD(P)+ | - |
Bos taurus | 5alpha-androstan-3,17-dione + NAD(P)H | - |
r | |
1.1.1.50 | benzoylpyridine + NADPH | - |
Bos taurus | ? | - |
? | |
1.1.1.50 | camphorquinone + NADPH | - |
Bos taurus | ? | - |
? | |
1.1.1.50 | hydroxybutyrate + NADP+ | - |
Bos taurus | oxobutanoate + NADPH | - |
? | |
1.1.1.50 | menadione + NADPH | - |
Bos taurus | ? | - |
? | |
1.1.1.50 | additional information | reduction of carbonyl compounds e.g. quinones, aliphatic-chain diketones, ketones | Bos taurus | ? | - |
? | |
1.1.1.50 | additional information | can not catalyze the dehydrogenation of 3beta-hydroxysteroids, epiandrosterone and 17beta-hydroxysteroids, i.e. testosterone and 17beta-estradiol | Bos taurus | ? | - |
? | |
1.1.1.50 | additional information | broad substrate range | Bos taurus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.50 | monomer | 1 * 35000, SDS-PAGE | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.50 | NADP+ | - |
Bos taurus | |
1.1.1.50 | NADPH | - |
Bos taurus |