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Literature summary extracted from

  • Vincent, M.; Gallay, J.; de Paillerets, C.; Alfsen, A.; Biellmann, J.F.
    Role of thiol group(s) in the enzymatic activity of the membrane-bound delta5-3beta-hydroxysteroid dehydrogenase from bovine adrenal cortex microsomes (1978), Biochim. Biophys. Acta, 525, 1-8.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.145 iodoacetamide
-
 Bos taurus
1.1.1.145 p-chloromercuribenzoate
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 3-Chloroacetylpyridine adenine dinucleotide
-
 Bos taurus
1.1.1.145 N-(Anilino-naphthyl-4)-maleimide
-
 Bos taurus
1.1.1.145 N-Iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylene diamine
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 additional information
-
 additional information
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 pregnenolone + NAD(P)+ Bos taurus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Bos taurus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Bos taurus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Bos taurus