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Literature summary extracted from
- Eukaryotic topoisomerase II. Characterization of enzyme turnover (1986), J. Biol. Chem., 261, 9944-9950.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.2 | Drosophila melanogaster | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.6.2.2 | ATP-dependent breakage, passage and rejoining of double-stranded DNA | characterization of interactions between topoisomerase II and DNA which occurs after DNA strand passage but before enzyme turnover | Drosophila melanogaster |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Drosophila melanogaster | monomeric DNA circles + ADP + phosphate | - |
? |  |
| 5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Drosophila melanogaster | catenated DNA networks + ADP + phosphate | - |
? | |
| 5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Drosophila melanogaster | relaxed DNA + ADP + phosphate | - |
? | |
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