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Literature summary extracted from

  • Arndt-Jovin, D.J.; Udvardy, A.; Garner, M.M.; Ritter, S.; Jovin, T.M.
    Z-DNA binding and inhibition of GTP of Drosophila topoisomerase II (1993), Biochemistry, 32, 4862-4872.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 GTP allosteric inhibition Drosophila melanogaster
5.6.2.2 GTP-gamma-S allosteric inhibition Drosophila melanogaster
5.6.2.2 Z-DNA inhibits relaxation of closed circular supercoiled DNA Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.2.2 additional information Drosophila melanogaster the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 embryo
-
 Drosophila melanogaster
-
5.6.2.2 tissue culture
-
 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 additional information enzyme binds Z-DNA with an affinity 2 orders of magnitude greater than that for B-DNA Drosophila melanogaster ?
-
 ?
5.6.2.2 additional information the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling Drosophila melanogaster ?
-
 ?
5.6.2.2 network of DNA rings + ATP + H2O decatenation Drosophila melanogaster monomeric DNA circles + ADP + phosphate
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 ?
5.6.2.2 supercoiled DNA + ATP + H2O catenation Drosophila melanogaster catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O relaxation Drosophila melanogaster relaxed DNA + ADP + phosphate
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 ?