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Literature summary extracted from

  • Yang, F.; Lu, G.; Rubin, H.
    Cloning, expression, purification and characterization of DNA topoisomerase I of Mycobacterium tuberculosis (1996), Gene, 178, 63-69.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.2.1 expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.1 spermidine
-
 Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.1 Mg2+ required Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.2.1 99353
-
 x * 99353, calculation from nucleotide sequence Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 Mycobacterium tuberculosis
-
 Erdman strain
-
5.6.2.1 Mycobacterium tuberculosis Erdman
-
 Erdman strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.2.1
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.1 supercoiled DNA relaxation Mycobacterium tuberculosis relaxed closed circular DNA
-
 ?
5.6.2.1 supercoiled DNA negatively supercoiled DNA Mycobacterium tuberculosis relaxed closed circular DNA
-
 ?
5.6.2.1 supercoiled DNA relaxation Mycobacterium tuberculosis Erdman relaxed closed circular DNA
-
 ?
5.6.2.1 supercoiled DNA negatively supercoiled DNA Mycobacterium tuberculosis Erdman relaxed closed circular DNA
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.2.1 ? x * 99353, calculation from nucleotide sequence Mycobacterium tuberculosis