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Literature summary extracted from

  • Minagawa, Y.; Kigawa, J.; Irie, T.; Kanamori, Y.; Itamochi, H.; Cheng, X.; Terakawa, N.
    Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines (1997), Jpn. J. Cancer Res., 88, 1218-1223.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.1 cisplatin synergistic action between cisplatin and 7-ethyl-10-hydroxy-camptothecin in Kfr cells, a cisplatin resistant subline of the KF epithelial ovarian carcinoma cell line but not in the parent KF cells eukaryota

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 eukaryota
-
-
-
5.6.2.1 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.1 ovarian cancer cell line a cisplatin resistant subline of the KF epithelial ovarian carcinoma cell line Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.1 supercoiled DNA relaxation Mammalia relaxed closed circular DNA
-
 ?
5.6.2.1 supercoiled DNA relaxation eukaryota relaxed closed circular DNA
-
 ?