Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miller, A.L.; Levy, H.R.
    Acetyl-CoA carboxylase from rat mammary gland (1975), Methods Enzymol., 35B, 11-17.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 bovine serum albumin
-
 Rattus norvegicus
6.4.1.2 citrate completely inactive in absence of the allosteric activator citrate Rattus norvegicus
6.4.1.2 citrate 6fold stimulation by 0.03 M citrate Rattus norvegicus
6.4.1.2 Phospholipids stimulate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 Avidin biotin prevents inhibition Rattus norvegicus
6.4.1.2 laurate
-
 Rattus norvegicus
6.4.1.2 malonyl-CoA
-
 Rattus norvegicus
6.4.1.2 Mg2+ at high concentrations Rattus norvegicus
6.4.1.2 myristate
-
 Rattus norvegicus
6.4.1.2 palmitoyl-CoA
-
 Rattus norvegicus
6.4.1.2 Rat milk
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.2 0.045
-
 propionyl-CoA
-
 Rattus norvegicus
6.4.1.2 0.05
-
 acetyl-CoA
-
 Rattus norvegicus
6.4.1.2 0.0588
-
 ATP second value 0.227 mM Rattus norvegicus
6.4.1.2 0.227
-
 ATP second value 0.0588 mM Rattus norvegicus
6.4.1.2 10
-
 HCO3-
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 Mg2+ activates Rattus norvegicus
6.4.1.2 Mn2+ activates Rattus norvegicus
6.4.1.2 Mn2+ maximal activity at 8 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 mammary gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + propionyl-CoA + HCO3- maximal rate is 20% of that for acetyl-CoA Rattus norvegicus ADP + phosphate + methylmalonyl-CoA
-
 ?
6.4.1.2 dATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus dADP + phosphate + malonyl-CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4.1.2 7.5
-
-
 Rattus norvegicus