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Literature summary extracted from

  • Hardie, D.G.; Guy, P.S.; Cohen, P.
    Acetyl-CoA carboxylase and fatty acid synthase from lactating rabbit and rat mammary gland (1981), Methods Enzymol., 71, 26-33.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 bovine serum albumin
-
 Rattus norvegicus
6.4.1.2 bovine serum albumin stimulates Oryctolagus cuniculus
6.4.1.2 citrate completely inactive in absence of the allosteric activator citrate Rattus norvegicus
6.4.1.2 citrate completely inactive in absence of the allosteric activator citrate Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 Mg2+
-
 Rattus norvegicus
6.4.1.2 Mg2+ concentration of Mg2+ must be sufficient to allow chelation by both ATP and citrate. Free Mg2+ inhibits Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.2 additional information
-
 linear polymers of MW several million Oryctolagus cuniculus
6.4.1.2 252000
-
 x * 252000, linear polymers of MW several million Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Oryctolagus cuniculus
-
-
-
6.4.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.2
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 mammary gland
-
 Rattus norvegicus
-
6.4.1.2 mammary gland
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 4.2
-
-
 Oryctolagus cuniculus

Storage Stability

EC Number Storage Stability Organism
6.4.1.2 -20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, 35% ethanediol, stable for at least 1 month Oryctolagus cuniculus
6.4.1.2 20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, stable for several days Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Oryctolagus cuniculus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 polymer
-
 Rattus norvegicus
6.4.1.2 polymer x * 252000, linear polymers of MW several million Oryctolagus cuniculus