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Literature summary extracted from
- Purification, structure, and catalytic properties of L-myo-inositol-1-phosphate synthase from rat testis (1980), J. Biol. Chem., 255, 8458-8464.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.5.1.4 | NH4+ | stimulates | Rattus norvegicus |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 5.5.1.4 | rapid loss of activity on freezing and thawing | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.5.1.4 | 2-Deoxy-D-glucitol 6-phosphate | - |
Rattus norvegicus | |
| 5.5.1.4 | 2-deoxy-D-glucose 6-phosphate | - |
Rattus norvegicus | |
| 5.5.1.4 | Cd2+ | - |
Rattus norvegicus | |
| 5.5.1.4 | Co2+ | - |
Rattus norvegicus | |
| 5.5.1.4 | Cu2+ | - |
Rattus norvegicus | |
| 5.5.1.4 | Hg2+ | - |
Rattus norvegicus | |
| 5.5.1.4 | Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.5.1.4 | 0.26 | - |
D-glucose 6-phosphate | with addition of 20 mM NH4Cl | Rattus norvegicus | |
| 5.5.1.4 | 3.89 | - |
D-glucose 6-phosphate | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.5.1.4 | K+ | stimulates 2fold and with added K+, 2.5fold | Rattus norvegicus | |
| 5.5.1.4 | Na+ | slight stimulation | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.5.1.4 | 68000 | - |
3 * 68000, SDS-PAGE | Rattus norvegicus |
| 5.5.1.4 | 210000 | - |
testis, gel filtration, PAGE, ultracentrifugal equilibrium sedimentation | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.5.1.4 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.5.1.4 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.5.1.4 | testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.5.1.4 | 0.26 | - |
- |
Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 5.5.1.4 | -20°C, partially purified enzyme is stable for several months | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.5.1.4 | D-Glucose 6-phosphate | - |
Rattus norvegicus | L-myo-Inositol 1-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.5.1.4 | trimer | 3 * 68000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.5.1.4 | 7.7 | - |
- |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.5.1.4 | NAD+ | required | Rattus norvegicus | |
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