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Literature summary extracted from
- Purification and characterization of cathepsin B from monkey skeletal muscle (1984), J. Biochem., 95, 871-879.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.1 | 2-mercaptoethanol | activates | Macaca fuscata |  |
| 3.4.22.1 | cysteine | activates | Macaca fuscata | |
| 3.4.22.1 | dithiothreitol | activates | Macaca fuscata | |
| 3.4.22.1 | thiol compounds | required for full activity | Macaca fuscata | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.1 | antipain | - |
Macaca fuscata | |
| 3.4.22.1 | chymostatin | - |
Macaca fuscata | |
| 3.4.22.1 | iodoacetic acid | - |
Macaca fuscata | |
| 3.4.22.1 | L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane | E-64 | Macaca fuscata | |
| 3.4.22.1 | leupeptin | - |
Macaca fuscata | |
| 3.4.22.1 | N-tosyl-lysyl chloromethylketone | - |
Macaca fuscata | |
| 3.4.22.1 | N-tosyl-phenylalanine chloromethylketone | - |
Macaca fuscata | |
| 3.4.22.1 | p-chloromercuribenzoate | - |
Macaca fuscata | |
| 3.4.22.1 | p-chloromercuriphenyl sulfonic acid | - |
Macaca fuscata | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.1 | 24000 | - |
gel filtration | Macaca fuscata |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.1 | Proteins + H2O | Macaca fuscata | muscle proteins | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.1 | Macaca fuscata | - |
monkey | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.22.1 | - |
Macaca fuscata |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.1 | muscle | - |
Macaca fuscata | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.1 | azocasein + H2O | poor substrate | Macaca fuscata | fragments of azocasein | - |
? | |
| 3.4.22.1 | benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide | - |
Macaca fuscata | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.22.1 | myosin + H2O | - |
Macaca fuscata | hydrolyzed myosin | - |
? | |
| 3.4.22.1 | neuropeptides + H2O | such as Leu-enkephalin, beta-neoendorphin, alpha-neoendorphin, dynorphin(1-13), substance P | Macaca fuscata | hydrolyzed neuropeptides | - |
? | |
| 3.4.22.1 | Proteins + H2O | muscle proteins | Macaca fuscata | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.1 | 4 | 5 | myosin as substrate | Macaca fuscata |
| 3.4.22.1 | 6.5 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide as substrate | Macaca fuscata |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.1 | 5.5 | 7 | activity decreases sharply above pH 7.0 | Macaca fuscata |
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