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Literature summary extracted from
- Cathepsins (1970), Methods Enzymol., 19, 285-315.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.1 | 2,3-Dimercaptopropanol | - |
Bos taurus |  |
| 3.4.22.1 | 2-mercaptoethanol | activates | Rattus norvegicus | |
| 3.4.22.1 | 2-mercaptoethanol | activates | Bos taurus | |
| 3.4.22.1 | 2-mercaptoethylamine | - |
Bos taurus | |
| 3.4.22.1 | cysteine | activates | Rattus norvegicus | |
| 3.4.22.1 | cysteine | activates | Bos taurus | |
| 3.4.22.1 | glutathione | activates | Bos taurus | |
| 3.4.22.1 | thiol compounds | required for full activity | Rattus norvegicus | |
| 3.4.22.1 | thiol compounds | required for full activity | Bos taurus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.1 | iodoacetamide | - |
Bos taurus | |
| 3.4.22.1 | N-ethylmaleimide | no inhibition at 1 mM | Bos taurus | |
| 3.4.22.1 | p-chloromercuribenzoate | - |
Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.22.1 | lysosome | - |
Bos taurus | 5764 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.1 | Proteins + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.1 | Proteins + H2O | Bos taurus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.1 | Bos taurus | - |
- |
- |
| 3.4.22.1 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.22.1 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.1 | spleen | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.1 | benzoyl-arginine ethyl ester + H2O | - |
Rattus norvegicus | benzoyl-arginine + ethanol | - |
? | |
| 3.4.22.1 | benzoyl-arginine ethyl ester + H2O | - |
Bos taurus | benzoyl-arginine + ethanol | - |
? | |
| 3.4.22.1 | benzoyl-DL-argininamide + H2O | - |
Rattus norvegicus | benzoyl-DL-arginine + NH3 | - |
? | |
| 3.4.22.1 | benzoyl-DL-argininamide + H2O | - |
Bos taurus | benzoyl-DL-arginine + NH3 | - |
? | |
| 3.4.22.1 | Proteins + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.1 | Proteins + H2O | - |
Bos taurus | ? | - |
? | |
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Release 2023.1 (January 2023)
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