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Literature summary extracted from

  • Frere, J.M.; Joris, B.
    Penicillin-sensitive enzymes in peptidoglycan biosynthesis (1985), CRC Crit. Rev. Microbiol., 11, 299-396.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.16.4 penicillin kinetic model of interaction Actinomadura sp.
3.4.16.4 penicillin kinetic model of interaction Streptomyces sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.16.4 0.1
-
 Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala 54000 MW enzyme Streptomyces sp.
3.4.16.4 12
-
 Nalpha, Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala lysozyme releasable enzyme Streptomyces sp.
3.4.16.4 14
-
 Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala
-
 Streptomyces sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.16.4 extracellular
-
 Streptomyces sp.
-
-
3.4.16.4 extracellular
-
 Actinomadura sp.
-
-
3.4.16.4 membrane
-
 Streptomyces sp. 16020
-
3.4.16.4 membrane
-
 Actinomadura sp. 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.16.4 53000
-
 gel filtration + mercaptoethanol, SDS-PAGE Streptomyces sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Streptomyces sp.
-
 ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Actinomadura sp.
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.4 Actinomadura sp.
-
 R39
-
3.4.16.4 Streptomyces sp.
-
 R61
-
3.4.16.4 Streptomyces sp.
-
 sp. K15
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.16.4 culture filtrate
-
 Streptomyces sp.
-
3.4.16.4 culture filtrate
-
 Actinomadura sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ir
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Actinomadura sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-lactate + H2O
-
 Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-lactate
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Streptomyces sp. ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Actinomadura sp. ?
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Actinomadura sp. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.16.4 additional information
-
 ratio of hydrolysis/transpeptidation depending on pH Streptomyces sp.
3.4.16.4 additional information
-
 ratio of hydrolysis/transpeptidation depending on pH Actinomadura sp.
3.4.16.4 6 8 hydrolysis, value increased by high ionic strength Streptomyces sp.
3.4.16.4 6 8 hydrolysis, value increased by high ionic strength Actinomadura sp.
3.4.16.4 8
-
 transpeptidation, Streptomyces sp. R61 Streptomyces sp.
3.4.16.4 9.5
-
 transpeptidation, Streptomyces sp. R39 Streptomyces sp.