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Literature summary extracted from

  • Yoshimoto, T.; Kita, T.; Ichinose, M.; Tsuru, D.
    Dipeptidyl aminopeptidase IV from porcine pancreas (1982), J. Biochem., 92, 275-282.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 1,10-phenanthroline slight Sus scrofa
3.4.14.5 diisopropyl fluorophosphate
-
 Sus scrofa
3.4.14.5 EDTA slight Sus scrofa
3.4.14.5 iodoacetate slight Sus scrofa
3.4.14.5 NEM slight Sus scrofa
3.4.14.5 PCMB slight Sus scrofa
3.4.14.5 phenylmethylsulfonyl fluoride slight Sus scrofa
3.4.14.5 Zn2+
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.5 0.57
-
 Gly-Pro-7-amido-4-methylcoumarin
-
 Sus scrofa
3.4.14.5 0.63
-
 Gly-Pro-4-nitroanilide
-
 Sus scrofa
3.4.14.5 0.82
-
 Ala-Ala-2-naphthylamide
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.5 115000
-
 2 * 115000, SDS-PAGE Sus scrofa
3.4.14.5 230000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.5
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 pancreas
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.14.5 9.29
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 Ala-Ala-2-naphthylamide + H2O
-
 Sus scrofa Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.5 Gly-Pro-2-naphthylamide + H2O
-
 Sus scrofa Gly-Pro + 2-naphthylamine
-
 ?
3.4.14.5 Gly-Pro-4-methylcoumarin 7-amide + H2O
-
 Sus scrofa Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.14.5 Gly-Pro-4-nitroanilide + H2O
-
 Sus scrofa Gly-Pro + 4-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.5 dimer 2 * 115000, SDS-PAGE Sus scrofa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.14.5 40
-
 pH 7.0, 1 h Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.5 8
-
 hydrolysis of Gly-Pro-2-naphthylamide Sus scrofa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.14.5 6.5 9 37°C, 1 h, stable Sus scrofa