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Literature summary extracted from

  • Huang, F.L.; Tappel, A.L.
    Properties of cathepsin C from rat liver (1972), Biochim. Biophys. Acta, 268, 527-538.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.14.1 beta-mercaptoethylamine SH compound required, efficient activator at 25 mM Rattus norvegicus
3.4.14.1 Cys L-Cys, SH compound required, efficient activator at 25 mM Rattus norvegicus
3.4.14.1 dithioerythritol SH compound required, efficient activator at 25 mM Rattus norvegicus
3.4.14.1 DL-homocysteine SH compound required, efficient activator at 25 mM Rattus norvegicus
3.4.14.1 GSH SH compound required, efficient activator at 25 mM Rattus norvegicus
3.4.14.1 mercaptoethanol SH compound required, efficient activator at 25 mM Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.1 iodoacetamide
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.1 2.5
-
 Val-Leu-NH2
-
 Rattus norvegicus
3.4.14.1 6
-
 Gly-Tyr-NH2
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.1 Br- absolute requirement for halide ions, 10 mM Cl- or Br- required Rattus norvegicus
3.4.14.1 Cl- absolute requirement for halide ions, 10 mM Cl- or Br- required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.1
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.14.1 91.6
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.1 Ala-Arg-NH2 + H2O
-
 Rattus norvegicus Ala-Arg + NH3
-
 ?
3.4.14.1 Ala-Leu-NH2 + H2O
-
 Rattus norvegicus Ala-Leu + NH3
-
 ?
3.4.14.1 Ala-Tyr-NH2 + H2O
-
 Rattus norvegicus Ala-Tyr + NH3
-
 ?
3.4.14.1 Gly-Ala-NH2 + H2O
-
 Rattus norvegicus Gly-Ala + NH3
-
 ?
3.4.14.1 Gly-Gly-Phe-NH2 + H2O
-
 Rattus norvegicus Gly-Gly + Phe-NH2
-
 ?
3.4.14.1 Gly-L-Phe-NH2 + H2O
-
 Rattus norvegicus Gly-L-Phe + NH3
-
 ?
3.4.14.1 Gly-L-Tyr-NH2 + H2O
-
 Rattus norvegicus Gly-L-Tyr + NH3
-
 ?
3.4.14.1 Gly-Leu-NH2 + H2O
-
 Rattus norvegicus Gly-Leu + NH3
-
 ?
3.4.14.1 Gly-Tyr-Gly + H2O
-
 Rattus norvegicus Gly-Tyr + Gly
-
 ?
3.4.14.1 His-Leu-NH2 + H2O
-
 Rattus norvegicus His-Leu + NH3
-
 ?
3.4.14.1 His-Tyr-NH2 + H2O
-
 Rattus norvegicus His-Tyr + NH3
-
 ?
3.4.14.1 Ile-Leu-NH2 + H2O
-
 Rattus norvegicus Ile-Leu + NH3
-
 ?
3.4.14.1 Leu-Tyr-NH2 + H2O
-
 Rattus norvegicus Leu-Tyr + NH3
-
 ?
3.4.14.1 Lys-Gly-NH2 + H2O
-
 Rattus norvegicus Lys-Gly + NH3
-
 ?
3.4.14.1 additional information the most favorable substrates are tripeptides or dipeptide amides that have as the NH2-terminal group a small residue and that have the aliphatic residue leucine at the penultimate position Rattus norvegicus ?
-
 ?
3.4.14.1 Pro-Leu-NH2 + H2O
-
 Rattus norvegicus Pro-Leu + NH3
-
 ?
3.4.14.1 Pro-Phe-NH2 + H2O
-
 Rattus norvegicus Pro-Phe + NH3
-
 ?
3.4.14.1 Ser-Leu-NH2 + H2O
-
 Rattus norvegicus Ser-Leu + NH3
-
 ?
3.4.14.1 Ser-Tyr-NH2 + H2O
-
 Rattus norvegicus Ser + Tyr + NH3
-
 ?
3.4.14.1 Thr-Leu-NH2 + H2O
-
 Rattus norvegicus Thr-Leu + NH3
-
 ?
3.4.14.1 Val-Leu-NH2 + H2O
-
 Rattus norvegicus Val-Leu + NH3
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.1 7.2 7.8
-
 Rattus norvegicus