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Literature summary extracted from

  • Kusano, M.; Abe, I.; Sankawa, U.; Ebizuka, Y.
    Purification and some properties of squalene 2,3-epoxide: lanosterol cyclase from rat liver (1991), Chem. Pharm. Bull., 39, 239-241.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.4.99.7 Triton X-100 0.05-0.15%, activates solubilized enzyme up to 300% Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 KCl 0-0.1 M: activity decreases with increasing concentration of KCl in the presence of optimal concentrations of Triton X-100 Rattus norvegicus
5.4.99.7 additional information no inhibition: cholesterol Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.7 0.055
-
 (3S)-squalene epoxide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.7 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.7 75000
-
 2 * 75000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.4.99.7 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (3S)-Squalene epoxide
-
 Rattus norvegicus ?
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Rattus norvegicus Lanosterol
-
 ?

Subunits

EC Number Subunits Comment Organism
5.4.99.7 dimer 2 * 75000, SDS-PAGE Rattus norvegicus