BRENDA - Enzyme Database

2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors

Cattel, L.; Ceruti, M.; Balliano, G.; Viola, F.; Grosa, G.; Rocco, F.; Brusa, P.; Lipids 30, 235-246 (1995)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Candida albicans
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Rattus norvegicus
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Saccharomyces cerevisiae
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Sus scrofa
5.4.99.7
19-Azasqualene
-
Candida albicans
5.4.99.7
19-Azasqualene
-
Rattus norvegicus
5.4.99.7
19-Azasqualene
-
Saccharomyces cerevisiae
5.4.99.7
19-Azasqualene
-
Sus scrofa
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Candida albicans
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Rattus norvegicus
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Saccharomyces cerevisiae
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Sus scrofa
5.4.99.7
2-Aza-2,3-dihydrosqualene
-
Rattus norvegicus
5.4.99.7
2-aza-2,3-dihydrosqualene alcohol
-
Rattus norvegicus
5.4.99.7
2-Aza-2,3-dihydrosqualene N-oxide
-
Rattus norvegicus
5.4.99.7
22,23-Epoxy-2-aza-2,3-dihydrosqualene
slight
Rattus norvegicus
5.4.99.7
Squalene maleimide
-
Rattus norvegicus
5.4.99.7
Squalene maleimide
-
Sus scrofa
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.4.99.7
microsome
-
Rattus norvegicus
-
-
5.4.99.7
microsome
-
Sus scrofa
-
-
5.4.99.7
microsome
-
Saccharomyces cerevisiae
-
-
5.4.99.7
microsome
-
Candida albicans
-
-
Organism
EC Number
Organism
UniProt
Commentary
Textmining
5.4.99.7
Candida albicans
-
-
-
5.4.99.7
Rattus norvegicus
-
-
-
5.4.99.7
Saccharomyces cerevisiae
-
-
-
5.4.99.7
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.99.7
liver
-
Rattus norvegicus
-
5.4.99.7
liver
-
Sus scrofa
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Rattus norvegicus
Lanosterol
-
3608
Rattus norvegicus
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Sus scrofa
Lanosterol
-
3608
Sus scrofa
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Saccharomyces cerevisiae
Lanosterol
-
3608
Saccharomyces cerevisiae
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Candida albicans
Lanosterol
-
3608
Candida albicans
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Candida albicans
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Rattus norvegicus
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Saccharomyces cerevisiae
5.4.99.7
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
Sus scrofa
5.4.99.7
19-Azasqualene
-
Candida albicans
5.4.99.7
19-Azasqualene
-
Rattus norvegicus
5.4.99.7
19-Azasqualene
-
Saccharomyces cerevisiae
5.4.99.7
19-Azasqualene
-
Sus scrofa
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Candida albicans
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Rattus norvegicus
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Saccharomyces cerevisiae
5.4.99.7
19-Azasqualene-2,3-epoxide
-
Sus scrofa
5.4.99.7
2-Aza-2,3-dihydrosqualene
-
Rattus norvegicus
5.4.99.7
2-aza-2,3-dihydrosqualene alcohol
-
Rattus norvegicus
5.4.99.7
2-Aza-2,3-dihydrosqualene N-oxide
-
Rattus norvegicus
5.4.99.7
22,23-Epoxy-2-aza-2,3-dihydrosqualene
slight
Rattus norvegicus
5.4.99.7
Squalene maleimide
-
Rattus norvegicus
5.4.99.7
Squalene maleimide
-
Sus scrofa
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.4.99.7
microsome
-
Rattus norvegicus
-
-
5.4.99.7
microsome
-
Sus scrofa
-
-
5.4.99.7
microsome
-
Saccharomyces cerevisiae
-
-
5.4.99.7
microsome
-
Candida albicans
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.99.7
liver
-
Rattus norvegicus
-
5.4.99.7
liver
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Rattus norvegicus
Lanosterol
-
3608
Rattus norvegicus
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Sus scrofa
Lanosterol
-
3608
Sus scrofa
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Saccharomyces cerevisiae
Lanosterol
-
3608
Saccharomyces cerevisiae
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3608
Candida albicans
Lanosterol
-
3608
Candida albicans
-