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Literature summary extracted from

  • Cattel, L.; Ceruti, M.; Balliano, G.; Viola, F.; Grosa, G.; Rocco, F.; Brusa, P.
    2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors (1995), Lipids, 30, 235-246.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Candida albicans
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Rattus norvegicus
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Saccharomyces cerevisiae
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Sus scrofa
5.4.99.7 19-Azasqualene
-
 Candida albicans
5.4.99.7 19-Azasqualene
-
 Rattus norvegicus
5.4.99.7 19-Azasqualene
-
 Saccharomyces cerevisiae
5.4.99.7 19-Azasqualene
-
 Sus scrofa
5.4.99.7 19-Azasqualene-2,3-epoxide
-
 Candida albicans
5.4.99.7 19-Azasqualene-2,3-epoxide
-
 Rattus norvegicus
5.4.99.7 19-Azasqualene-2,3-epoxide
-
 Saccharomyces cerevisiae
5.4.99.7 19-Azasqualene-2,3-epoxide
-
 Sus scrofa
5.4.99.7 2-Aza-2,3-dihydrosqualene
-
 Rattus norvegicus
5.4.99.7 2-aza-2,3-dihydrosqualene alcohol
-
 Rattus norvegicus
5.4.99.7 2-Aza-2,3-dihydrosqualene N-oxide
-
 Rattus norvegicus
5.4.99.7 22,23-Epoxy-2-aza-2,3-dihydrosqualene slight Rattus norvegicus
5.4.99.7 Squalene maleimide
-
 Rattus norvegicus
5.4.99.7 Squalene maleimide
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.7 microsome
-
 Rattus norvegicus
-
-
5.4.99.7 microsome
-
 Sus scrofa
-
-
5.4.99.7 microsome
-
 Saccharomyces cerevisiae
-
-
5.4.99.7 microsome
-
 Candida albicans
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Candida albicans
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-
5.4.99.7 Saccharomyces cerevisiae
-
-
-
5.4.99.7 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 liver
-
 Rattus norvegicus
-
5.4.99.7 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Rattus norvegicus Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Sus scrofa Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Saccharomyces cerevisiae Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Candida albicans Lanosterol
-
 ?