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Literature summary extracted from

  • Sarid, S.; Berger, A.; Katchalski, E.
    Proline iminopeptidase. II. Purification and comparison with iminodipeptidase (prolidase) (1962), J. Biol. Chem., 237, 2207-2212.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.5 Cd2+
-
 Escherichia coli
3.4.11.5 p-chloromercuribenzoate enzyme I Brevibacillus brevis
3.4.11.5 p-chloromercuribenzoate enzyme I Escherichia coli
3.4.11.5 p-chloromercuribenzoate enzyme I Gallus gallus
3.4.11.5 p-chloromercuribenzoate enzyme I Oryctolagus cuniculus
3.4.11.5 p-chloromercuribenzoate enzyme I Rattus norvegicus
3.4.11.5 p-chloromercuribenzoate enzyme I Sus scrofa
3.4.13.18 bestatin
-
 Sus scrofa
3.4.13.18 CdCl2
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.5 Mn2+ inactive in absence of Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.5 Brevibacillus brevis
-
-
-
3.4.11.5 Escherichia coli
-
-
-
3.4.11.5 Gallus gallus
-
-
-
3.4.11.5 Oryctolagus cuniculus
-
-
-
3.4.11.5 Rattus norvegicus
-
-
-
3.4.11.5 Sus scrofa
-
-
-
3.4.13.18 Escherichia coli
-
-
-
3.4.13.18 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.5
-
 Escherichia coli
3.4.13.18
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.5 kidney
-
 Rattus norvegicus
-
3.4.11.5 kidney cortex Sus scrofa
-
3.4.11.5 additional information almost all organs Gallus gallus
-
3.4.11.5 additional information almost all organs Rattus norvegicus
-
3.4.11.5 additional information almost all organs Sus scrofa
-
3.4.11.5 additional information almost all organs Oryctolagus cuniculus
-
3.4.13.18 brain
-
 Sus scrofa
-
3.4.13.18 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.13.18 additional information
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Gallus gallus L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Brevibacillus brevis L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Escherichia coli L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Rattus norvegicus L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Sus scrofa L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-hydroxyproline-2-naphthylamide + H2O no hydrolysis Oryctolagus cuniculus L-hydroxyproline + 2-naphthylamine
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Gallus gallus L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Brevibacillus brevis L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Escherichia coli L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Rattus norvegicus L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Sus scrofa L-proline + peptide
-
 ?
3.4.11.5 L-prolyl-peptide + H2O influence of amino acid adjacent to N-terminal L-Pro on rate of hydrolysis Oryctolagus cuniculus L-proline + peptide
-
 ?
3.4.13.18 additional information
-
 Escherichia coli ?
-
 ?
3.4.13.18 additional information some activity against peptides with 3 or more residues but none against peptides containing acidic or D-amino acids Sus scrofa ?
-
 ?
3.4.13.18 Pro-Gly + H2O
-
 Sus scrofa Pro + Gly
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.5 8
-
-
 Escherichia coli