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Literature summary extracted from

  • Serfozo, P.; Tipton, P.A.
    Substrate determinants of the course of tartrate dehydrogenase-catalyzed reactions (1995), Biochemistry, 34, 7517-7524.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.7 gene encoding TDH cloned into the pET3a expression vector Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.93 0.011
-
 (2R,3S)-3-bromomalate
-
 Pseudomonas putida
1.1.1.93 0.012
-
 (2R,3S)-3-chloromalate
-
 Pseudomonas putida
1.1.1.93 0.019
-
 (2R,3S)-3-fluoromalate
-
 Pseudomonas putida
1.1.1.93 0.026
-
 (2R,3S)-3-aminomalate
-
 Pseudomonas putida
1.1.1.93 0.027
-
 (2R,3R)-3-iodomalate
-
 Pseudomonas putida
1.1.1.93 0.05
-
 D-malate
-
 Pseudomonas putida
1.1.1.93 0.06
-
 meso-tartrate
-
 Pseudomonas putida
1.1.1.93 0.06
-
 (2R,3R)-3-methyltartrate
-
 Pseudomonas putida
1.1.1.93 0.07
-
 (2R,3R)-3-methyltartrate
-
 Pseudomonas putida
1.1.1.93 0.22
-
 (2R,3R)-3-bromomalate
-
 Pseudomonas putida
1.1.1.93 0.27
-
 (2R,3R)-3-chloromalate
-
 Pseudomonas putida
1.1.1.93 0.58
-
 (2R,3R)-3-aminomalate
-
 Pseudomonas putida
1.1.1.93 0.67
-
 (2R,3R)-3-fluoromalate
-
 Pseudomonas putida
1.1.1.93 1
-
 L-Tartrate
-
 Pseudomonas putida
1.3.1.7 0.011
-
 (2R,3S)-3-bromomalate
-
 Escherichia coli
1.3.1.7 0.012
-
 (2R,3S)-3-chloromalate
-
 Escherichia coli
1.3.1.7 0.019
-
 (2R,3S)-3-fluoromalate
-
 Escherichia coli
1.3.1.7 0.024
-
 (2R,3R)-3-iodomalate
-
 Escherichia coli
1.3.1.7 0.027
-
 (2R,3S)-3-iodomalate
-
 Escherichia coli
1.3.1.7 0.05
-
 D-malate
-
 Escherichia coli
1.3.1.7 0.06
-
 meso-tartrate
-
 Escherichia coli
1.3.1.7 0.06
-
 (2R,3R)-3-methyltartrate
-
 Escherichia coli
1.3.1.7 0.07
-
 (2R,3S)-3-methyltartrate
-
 Escherichia coli
1.3.1.7 0.1
-
 (+)-tartrate
-
 Escherichia coli
1.3.1.7 0.22
-
 (2R,3R)-3-bromomalate
-
 Escherichia coli
1.3.1.7 0.27
-
 (2R,3R)-3-chloromalate
-
 Escherichia coli
1.3.1.7 0.67
-
 (2R,3R)-3-fluoromalate
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.93 Pseudomonas putida
-
 expression by Escherichia coli
-
1.3.1.7 Escherichia coli
-
-
-
1.3.1.7 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.7
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.93 (2R,3R)-3-aminomalate + NAD+
-
 Pseudomonas putida ?
-
 r
1.1.1.93 (2R,3R)-3-bromomalate + NAD+
-
 Pseudomonas putida 3-bromopyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3R)-3-chloromalate + NAD+
-
 Pseudomonas putida 3-chloropyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3R)-3-fluoromalate + NAD+
-
 Pseudomonas putida 3-fluoropyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3R)-3-iodomalate + NAD+
-
 Pseudomonas putida 3-iodopyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3R)-3-methyltartrate + NAD+
-
 Pseudomonas putida ? + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-aminomalate + NAD+
-
 Pseudomonas putida 3-aminopyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-bromomalate + NAD+
-
 Pseudomonas putida 3-bromopyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-chloromalate + NAD+
-
 Pseudomonas putida 3-chloropyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-fluoromalate + NAD+
-
 Pseudomonas putida 3-fluoropyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-iodomalate + NAD+
-
 Pseudomonas putida 3-iodopyruvate + NADH + CO2
-
 ?
1.1.1.93 (2R,3S)-3-methyltartrate + NAD+
-
 Pseudomonas putida ? + NADH + CO2
-
 ?
1.1.1.93 D-malate + NAD+
-
 Pseudomonas putida pyruvate + CO2 + NADH
-
 ?
1.1.1.93 L-tartrate + NAD+
-
 Pseudomonas putida oxaloglycolate + NADH + H+
-
 ?
1.1.1.93 meso-tartrate + NAD+
-
 Pseudomonas putida oxaloglycolate + NADH + H+
-
 ?
1.3.1.7 (2R,3R)-3-bromomalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3R)-3-chloromalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3R)-3-fluoromalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3R)-3-iodomalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3R)-3-methyltartrate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3R)-3-thiomalate + NAD+
-
 Escherichia coli ?
-
 ?
1.3.1.7 (2R,3S)-3-bromomalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3S)-3-chloromalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3S)-3-fluoromalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3S)-3-iodomalate + NAD+ oxidative decarboxylation Escherichia coli ? + CO2 + NADH
-
 ?
1.3.1.7 (2R,3S)-3-methyltartrate + NAD+ simple oxidation Escherichia coli ? + NADH
-
 ?
1.3.1.7 (2R,3S)-3-thiomalate + NAD+ net non-oxidative decarboxylation Escherichia coli ?
-
 ?
1.3.1.7 D-malate + NAD+
-
 Escherichia coli pyruvate + CO2 + NADH
-
 r
1.3.1.7 L-(+)-tartrate + NAD+
-
 Pseudomonas putida (3R)-oxaloglycolate + NADH
-
 ?
1.3.1.7 L-(+)-tartrate + NAD+ in presence of Mn2+ and K+ (+)-tartrate is subject to NAD+-dependent oxidation to form oxaloglycolate Escherichia coli (3R)-oxaloglycolate + NADH
-
 ?
1.3.1.7 malate + NAD+
-
 Escherichia coli pyruvate + CO2 + NADH + H+
-
 ?
1.3.1.7 meso-tartrate + NAD+
-
 Escherichia coli D-glycerate + CO2 + NADH + H+
-
 ?
1.3.1.7 additional information 3R-oxaloglycolate, (2R,3S)-3-aminomalate and (2R,3R)-3-aminomalate are no substrates Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.7 tartrate dehydrogenase
-
 Escherichia coli
1.3.1.7 TDH
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.93 NAD+ cofactor Pseudomonas putida