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Literature summary extracted from
- Sterol biosynthesis: Strong inhibition of maize DELTA5,7-sterol DELTA7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction (1996), Biochemistry, 35, 7069-7076.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.21 | 6,7-diaza-5alpha-cholest-8(14)-en-3beta-ol | - |
Zea mays |  |
| 1.3.1.21 | 6,7-diaza-5beta-cholest-8(14)-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | 6-aza-B-homo-5alpha-cholest-7-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | 6-aza-B-homo-5alpha-cholest-8-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | 8beta-cyano-6,7-diaza-5alpha-cholest-5-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | cholest-5,7-dien-3beta-ol | - |
Zea mays | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.3.1.21 | microsome | - |
Zea mays | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.21 | cholesta-5,7-dien-3-beta-ol + NADPH | Zea mays | - |
cholesterol + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.21 | Zea mays | - |
maize | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.3.1.21 | cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ | carbocationic intermediate, mechanism | Zea mays |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.1.21 | seedling | - |
Zea mays | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.21 | cholesta-5,7-dien-3-beta-ol + NADPH | - |
Zea mays | cholesterol + NADP+ | - |
? | |
| 1.3.1.21 | cholesta-5,7-dien-3beta-ol + NADPH | - |
Zea mays | cholesterol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.21 | DELTA5,7-sterol DELTA7-reductase | - |
Zea mays |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.21 | 30 | - |
assay at | Zea mays |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.21 | NADPH | - |
Zea mays | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.21 | 0.00005 | - |
6,7-diaza-5alpha-cholest-8(14)-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | 0.00007 | - |
6-aza-B-homo-5alpha-cholest-7-en-3beta-ol | - |
Zea mays | |
| 1.3.1.21 | 0.5 | - |
cholest-5,7-dien-3beta-ol | - |
Zea mays | |
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