EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.104 | acetyl-CoA | reversed by CoA | Escherichia coli | |
1.2.1.104 | additional information | not inhibited by ATP | Escherichia coli | |
1.2.1.104 | phosphorylation | - |
Bos taurus | |
1.2.1.104 | phosphorylation | - |
Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.104 | additional information | - |
- |
Bos taurus |
1.2.1.104 | additional information | - |
MW of native complex from heart: 740000 Da | Sus scrofa |
2.3.1.61 | 1000000 | - |
- |
Escherichia coli |
2.3.1.61 | 1000000 | - |
- |
Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.61 | succinyl-CoA + dihydrolipoamide | Escherichia coli | - |
CoA + S-succinyldihydrolipoamide | - |
? | |
2.3.1.61 | succinyl-CoA + dihydrolipoamide | Sus scrofa | - |
CoA + S-succinyldihydrolipoamide | - |
? | |
2.3.1.61 | succinyl-CoA + dihydrolipoamide | Bos taurus | - |
CoA + S-succinyldihydrolipoamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.104 | Bos taurus | - |
- |
- |
1.2.1.104 | Escherichia coli | - |
- |
- |
1.2.1.104 | Sus scrofa | - |
- |
- |
1.2.1.105 | Bos taurus | - |
- |
- |
1.2.1.105 | Escherichia coli | - |
- |
- |
1.2.1.105 | Sus scrofa | - |
- |
- |
2.3.1.61 | Bos taurus | - |
- |
- |
2.3.1.61 | Escherichia coli | - |
- |
- |
2.3.1.61 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.2.1.104 | additional information | not regulated by phosphorylation/dephosphorylation | Escherichia coli |
1.2.1.104 | side-chain modification | - |
Bos taurus |
1.2.1.104 | side-chain modification | inactivated by phosphorylation | Sus scrofa |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) | Escherichia coli | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) | Sus scrofa | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) | Bos taurus | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Escherichia coli | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Sus scrofa | |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.105 | heart | - |
Sus scrofa | - |
1.2.1.105 | heart | - |
Bos taurus | - |
1.2.1.105 | kidney | - |
Sus scrofa | - |
1.2.1.105 | kidney | - |
Bos taurus | - |
2.3.1.61 | heart | - |
Sus scrofa | - |
2.3.1.61 | kidney | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Escherichia coli | S-succinyldihydrolipoamide + CO2 | - |
? | |
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Sus scrofa | S-succinyldihydrolipoamide + CO2 | - |
? | |
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Bos taurus | S-succinyldihydrolipoamide + CO2 | - |
? | |
2.3.1.61 | succinyl-CoA + dihydrolipoamide | - |
Escherichia coli | CoA + S-succinyldihydrolipoamide | - |
? | |
2.3.1.61 | succinyl-CoA + dihydrolipoamide | - |
Sus scrofa | CoA + S-succinyldihydrolipoamide | - |
? | |
2.3.1.61 | succinyl-CoA + dihydrolipoamide | - |
Bos taurus | CoA + S-succinyldihydrolipoamide | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.61 | polymer | consists of 8 morphological subunits arranged in a cube-like structure | Escherichia coli |