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Literature summary extracted from

  • Eckfeldt, J.H.; Yonetani, T.
    Isozymes of aldehyde dehydrogenase from horse liver (1982), Methods Enzymol., 89, 474-479.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.5 Chloral hydrate
-
 Equus caballus
1.2.1.5 Disulfiram
-
 Equus caballus
1.2.1.5 p-hydroxymercuribenzoate
-
 Equus caballus
1.2.1.5 PCMB
-
 Equus caballus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.5 0.0001
-
 pentanal isoenzyme F1 Equus caballus
1.2.1.5 0.0002
-
 acetaldehyde isoenzyme F2 Equus caballus
1.2.1.5 0.0003
-
 phenylacetaldehyde isoenzyme F2 Equus caballus
1.2.1.5 0.0005
-
 isopentanal isoenzyme F1 Equus caballus
1.2.1.5 0.003
-
 NAD+ isoenzyme F1 Equus caballus
1.2.1.5 0.004
-
 phenylacetaldehyde isoenzyme F1 Equus caballus
1.2.1.5 0.005
-
 propanal isoenzyme F1 Equus caballus
1.2.1.5 0.01
-
 NADP+ isoenzyme F2 Equus caballus
1.2.1.5 0.01
-
 Chloroacetaldehyde isoenzyme F2 Equus caballus
1.2.1.5 0.03
-
 NAD+ isoenzyme F2 Equus caballus
1.2.1.5 0.03
-
 Chloroacetaldehyde isoenzyme F1 Equus caballus
1.2.1.5 0.05
-
 glycolaldehyde isoenzyme F2 Equus caballus
1.2.1.5 0.07
-
 acetaldehyde isoenzyme F1 Equus caballus
1.2.1.5 0.13
-
 glycolaldehyde isoenzyme F1 Equus caballus
1.2.1.5 0.27
-
 formaldehyde isoenzyme F2 Equus caballus
1.2.1.5 0.7
-
 NADP+ isoenzyme F1 Equus caballus
1.2.1.5 0.94
-
 formaldehyde isoenzyme F1 Equus caballus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.5 52000
-
 4 * 52000, isoenzyme F1, SDS-PAGE Equus caballus
1.2.1.5 53000
-
 4 * 53000, isoenzyme F2, SDS-PAGE Equus caballus
1.2.1.5 230000
-
 isoenzyme F1, non-denaturing PAGE Equus caballus
1.2.1.5 240000
-
 isoenzyme F2, non-denaturing PAGE Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Equus caballus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5 isoenzyme F1 and F2 Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.5 0.8
-
-
 Equus caballus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 acetaldehyde + NAD+ + H2O
-
 Equus caballus acetate + NADH + H+
-
 ?
1.2.1.5 benzaldehyde + NAD+ + H2O
-
 Equus caballus benzoate + NADH + H+
-
 ?
1.2.1.5 chloroacetaldehyde + NAD+ + H2O
-
 Equus caballus chloroacetate + NADH + H+
-
 ?
1.2.1.5 cinnamaldehyde + NAD+ + H2O
-
 Equus caballus cinnamate + NADH + H+
-
 ?
1.2.1.5 formaldehyde + NAD+ + H2O
-
 Equus caballus formate + NADH + H+
-
 ?
1.2.1.5 glycolaldehyde + NAD+
-
 Equus caballus glycolate + NADH
-
 ?
1.2.1.5 isopentanal + NAD+ + H2O
-
 Equus caballus isopentanoate + NADH + H+
-
 ?
1.2.1.5 n-pentanal + NAD+ + H2O
-
 Equus caballus n-pentanoate + NADH + H+
-
 ?
1.2.1.5 phenylacetaldehyde + NAD+ + H2O
-
 Equus caballus phenylacetate + NADH + H+
-
 ?
1.2.1.5 propanal + NAD+ + H2O
-
 Equus caballus propionate + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.5 tetramer 4 * 52000, isoenzyme F1, SDS-PAGE Equus caballus
1.2.1.5 tetramer 4 * 53000, isoenzyme F2, SDS-PAGE Equus caballus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.5 NAD+ relative but not absolute specificity for NAD+ over NADP+ Equus caballus
1.2.1.5 NADP+ relative but not absolute specificity for NAD+ over NADP+ Equus caballus