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Literature summary extracted from

  • Koivula, T.; Koivusalo, M.
    Partial purification and properties of a phenobarbital-induced aldehyde dehydrogenase of rat liver (1975), Biochim. Biophys. Acta, 410, 1-11.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.3 deoxycorticosterone activates Rattus norvegicus
1.2.1.3 diethylstilbestrol activates Rattus norvegicus
1.2.1.3 estrone activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Disulfiram
-
 Rattus norvegicus
1.2.1.3 EDTA
-
 Rattus norvegicus
1.2.1.3 additional information substrate inhibition by aromatic aldehydes Rattus norvegicus
1.2.1.3 progesterone
-
 Rattus norvegicus
1.2.1.3 sodium arsenite
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.035
-
 NAD+
-
 Rattus norvegicus
1.2.1.3 0.55
-
 propanal
-
 Rattus norvegicus
1.2.1.3 4
-
 acetaldehyde
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytoplasm
-
 Rattus norvegicus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 partial, phenobarbital-induced enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 4-carboxybenzaldehyde + NAD+ + H2O
-
 Rattus norvegicus 4-carboxybenzoate + NADH
-
 ?
1.2.1.3 4-chlorobenzaldehyde + NAD+ + H2O
-
 Rattus norvegicus 4-chlorobenzoate + NADH
-
 ?
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Rattus norvegicus acetate + NADH + H+
-
 ?
1.2.1.3 anisaldehyde + NAD+ + H2O
-
 Rattus norvegicus ? + NADH
-
 ?
1.2.1.3 benzaldehyde + NAD+ + H2O
-
 Rattus norvegicus benzoate + NADH + H+
-
 ?
1.2.1.3 butanal + NAD+ + H2O n-butanal Rattus norvegicus butyrate + NADH + H+
-
 ?
1.2.1.3 formaldehyde + NAD+ + H2O no activity Rattus norvegicus formate + NADH
-
 ?
1.2.1.3 hexanal + NAD+ + H2O
-
 Rattus norvegicus hexanoate + NADH + H+
-
 ?
1.2.1.3 m-nitrobenzaldehyde + NAD+ + H2O
-
 Rattus norvegicus m-nitrobenzoate + NADH
-
 ?
1.2.1.3 p-methoxybenzaldehyde + NAD+ + H2O
-
 Rattus norvegicus p-methoxybenzoate + NADH + H+
-
 ?
1.2.1.3 phenylacetaldehyde + NAD+ + H2O
-
 Rattus norvegicus phenylacetate + NADH + H+
-
 ?
1.2.1.3 propanal + NAD+ + H2O
-
 Rattus norvegicus propionate + NADH
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.3 additional information
-
 heat denaturation at 57°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 9.2 9.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Rattus norvegicus