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Literature summary extracted from

  • Kjonaas, R.; Martinkus-Taylor, C.; Croteau, R.
    Metabolism of monoterpenes: Conversion of l-menthone tol-menthole and d-neomenthol by stereospecific dehydrogenases from peppermint (Mentha piperita) leaves (1982), Plant Physiol., 69, 1013-1017.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.207 Hg2+ almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.207 iodoacetamide almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.207 N-ethylmaleimide almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.207 p-hydroxymercuribenzoate almost complete inhibition at 0.05 mM Mentha x piperita
1.1.1.208 Hg2+ almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.208 iodoacetamide almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.208 N-ethylmaleimide almost complete inhibition at 0.25 mM Mentha x piperita
1.1.1.208 p-hydroxymercuribenzoate almost complete inhibition at 0.05 mM Mentha x piperita

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.207 0.015
-
 NADPH
-
 Mentha x piperita
1.1.1.207 0.25
-
 (-)-menthone
-
 Mentha x piperita
1.1.1.208 0.022
-
 NADPH (-)-menthone Mentha x piperita

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.207 35000
-
 gel filtration Mentha x piperita
1.1.1.208 35000
-
 gel filtration Mentha x piperita

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.207 (1R)-menthone + NADPH + H+ Mentha x piperita ? (1R)-menthol + NADP+
-
 ?
1.1.1.208 (-)-menthone + NADPH + H+ Mentha x piperita ? (+)-neomenthol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.207 Mentha x piperita
-
 peppermint
-
1.1.1.208 Mentha x piperita
-
 peppermint
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.207
-
 Mentha x piperita
1.1.1.208
-
 Mentha x piperita

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.207 (-)-menthone + NADPH
-
 Mentha x piperita (3R)-menthol + NADP+
-
 ?
1.1.1.207 (1R)-menthone + NADPH + H+ ir Mentha x piperita (1R)-menthol + NADP+
-
 ?
1.1.1.207 (1R)-menthone + NADPH + H+ ? Mentha x piperita (1R)-menthol + NADP+
-
 ?
1.1.1.207 d-isomenthone + NADPH ? Mentha x piperita d-neoisomenthol + NADP+
-
 ?
1.1.1.208 (-)-menthone + NADPH + H+ ir Mentha x piperita (+)-neomenthol + NADP+
-
 ?
1.1.1.208 (-)-menthone + NADPH + H+ ? Mentha x piperita (+)-neomenthol + NADP+
-
 ?
1.1.1.208 d-isomenthone + NADPH ? Mentha x piperita d-isomenthol + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.207 7.5
-
 (-)-menthone + NADPH Mentha x piperita
1.1.1.208 7.6
-
 (-)-menthone + NADPH Mentha x piperita

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.207 NADPH NADH far less effective Mentha x piperita
1.1.1.208 NADPH
-
 Mentha x piperita