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Literature summary extracted from

  • Thong, K.W.; Coombs, G.H.
    Homocysteine desulphurase activity in trichomonads (1985), IRCS Med. Sci. Libr. Compend., 13, 493-494.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.2 DL-Penicillamine
-
 Trichomonas vaginalis
4.4.1.2 DL-propargylglycine
-
 Trichomonas vaginalis
4.4.1.2 hydroxylamine
-
 Trichomonas vaginalis
4.4.1.2 L-Cycloserine
-
 Trichomonas vaginalis

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.2 no activity in Crithidia fasciculata
-
-
-
4.4.1.2 no activity in Entamoeba histolytica
-
-
-
4.4.1.2 no activity in Escherichia coli
-
-
-
4.4.1.2 no activity in Herpetomonas muscarum
-
-
-
4.4.1.2 no activity in Leishmania mexicana mexicana
-
 amastigotes and promastigotes
-
4.4.1.2 no activity in Leishmania tarentolae
-
-
-
4.4.1.2 no activity in mouse
-
 liver
-
4.4.1.2 no activity in Tetrahymena pyriformis
-
-
-
4.4.1.2 no activity in Trichomonas foetus
-
-
-
4.4.1.2 Trichomonas batrachorum
-
 weak
-
4.4.1.2 Trichomonas vaginalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.2 L-homocysteine + H2O
-
 Trichomonas vaginalis H2S + NH3 + 2-oxobutanoate
-
 ?
4.4.1.2 L-homocysteine + H2O
-
 Trichomonas batrachorum H2S + NH3 + 2-oxobutanoate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4.1.2 7.5
-
-
 Trichomonas vaginalis