Literature summary extracted from

Matsuo, Y.; Greenberg, D.M.
A crystalline enzyme that cleaves homoserine and cystathionine (1958), J. Biol. Chem., 234, 507-515.

Inhibitors

EC Number	Inhibitors	Comment	Organism
4.4.1.1	1,10-phenanthroline	2 mM, 20% inhibition	Rattus norvegicus
4.4.1.1	1-nitroso-2-naphthol-3,6-disulfonic acid	2 mM, 55% inhibition	Rattus norvegicus
4.4.1.1	8-Hydroxyquinoline-5-sulfonic acid	2 mM, 13% inhibition	Rattus norvegicus
4.4.1.1	Ca2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Cd2+	strong	Rattus norvegicus
4.4.1.1	Co2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Cr2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Cu2+	strong	Rattus norvegicus
4.4.1.1	Cys	-	Rattus norvegicus
4.4.1.1	EDTA	2 mM, 13% inhibition	Rattus norvegicus
4.4.1.1	Fe2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Fe3+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Hg2+	strong	Rattus norvegicus
4.4.1.1	hydroxylamine	-	Rattus norvegicus
4.4.1.1	Iodosobenzoate	-	Rattus norvegicus
4.4.1.1	Isonicotinic acid hydrazide	-	Rattus norvegicus
4.4.1.1	Mg2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	Mn2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	additional information	inhibitory effect of the chelating agents and related compounds is at least partly and in some instances completely eliminated in the presence of an increased concentration of pyridoxal 5'-phosphate	Rattus norvegicus
4.4.1.1	NEM	0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol	Rattus norvegicus
4.4.1.1	Ni2+	0.1 mM, weak	Rattus norvegicus
4.4.1.1	PCMB	0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol	Rattus norvegicus
4.4.1.1	Sodium bisulfite	-	Rattus norvegicus
4.4.1.1	Sodium borohydride	-	Rattus norvegicus
4.4.1.1	Zn2+	0.1 mM, weak	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.4.1.1	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.4.1.1	liver	-	Rattus norvegicus	-