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Literature summary extracted from

  • Klee, C.B.; Kirk, K.L.; Cohen, L.A.; McPhie, P.
    Histidine ammonia-lyase. The use of 4-fluorohistidine in identification of the rate-determining step (1975), J. Biol. Chem., 250, 5033-5040.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 5-fluoro-L-histidine competitive Pseudomonas sp.
4.3.1.3 L-N-gamma-methylhistidine weak competitive Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.3 additional information
-
 additional information
-
 Pseudomonas sp.
4.3.1.3 1.25
-
 4-fluoro-DL-histidine in the presence of 0.1 mM CdCl2 Pseudomonas sp.
4.3.1.3 2.7
-
 DL-histidine in the presence of 0.1 mM CdCl2 Pseudomonas sp.
4.3.1.3 3
-
 Urocanate
-
 Pseudomonas sp.
4.3.1.3 5
-
 4-fluorourocanate
-
 Pseudomonas sp.
4.3.1.3 6.4
-
 4-fluoro-DL-histidine in the presence of 1 mM EDTA Pseudomonas sp.
4.3.1.3 10
-
 DL-histidine in the presence of 1 mM EDTA Pseudomonas sp.
4.3.1.3 20
-
 2-fluorohistidine
-
 Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Pseudomonas sp.
-
 ATCC 11,299b
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.3.1.3 L-histidine = urocanate + NH3 mechanism Pseudomonas sp.
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.3 additional information
-
-
 Pseudomonas sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 2-fluorohistidine
-
 Pseudomonas sp. 2-fluorourocanate + NH3
-
 ?
4.3.1.3 4-fluoro-DL-histidine very poor substrate Pseudomonas sp. 4-fluorourocanate + NH3
-
 r
4.3.1.3 DL-histidine
-
 Pseudomonas sp. urocanate + NH3
-
 ?
4.3.1.3 L-histidine natural substrate Pseudomonas sp. urocanate + NH3
-
 r

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.3.1.3 additional information
-
-
 Pseudomonas sp.