Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mehler, A.H.; Tabor, H.
    Deamination of histidine to form urocanic acid in liver (1953), J. Biol. Chem., 201, 775-784.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 CN- 0.01 M, 40% inhibition Cavia porcellus
4.3.1.3 EDTA 0.001 mM: 50% inhibition, 0.01 mM, complete inhibition Cavia porcellus
4.3.1.3 glycine 0.02 M glycine buffer, 40% inhibition. Inhibition can be overcome by addition of cations, including Mn2+, Ca2+, and Mg2+ Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.3 additional information Cavia porcellus pathway of histidine metabolism, enzymatical synthesis of urocanic acid ?
-
 ?
4.3.1.3 additional information Pseudomonas fluorescens pathway of histidine metabolism, enzymatical synthesis of urocanic acid ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Cavia porcellus
-
-
-
4.3.1.3 Pseudomonas fluorescens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.3 liver
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.3 additional information
-
-
 Cavia porcellus
4.3.1.3 additional information
-
-
 Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 L-histidine natural substrate Cavia porcellus urocanate + NH3
-
 ?
4.3.1.3 L-histidine natural substrate Pseudomonas fluorescens urocanate + NH3
-
 ?
4.3.1.3 additional information pathway of histidine metabolism, enzymatical synthesis of urocanic acid Cavia porcellus ?
-
 ?
4.3.1.3 additional information pathway of histidine metabolism, enzymatical synthesis of urocanic acid Pseudomonas fluorescens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.1.3 0.001
-
 EDTA
-
 Cavia porcellus