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Literature summary extracted from

  • Pickworth Glusker, J.
    Aconitase (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 5, 413-439.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.3 1,10-phenanthroline noncompetitive Bacillus subtilis
4.2.1.3 1,2,3,4-tetracarboxycyclopentane competitive Sus scrofa
4.2.1.3 1,2,3-tricarboxycyclopentene-1 competitive Sus scrofa
4.2.1.3 1,3,5-tricarboxypentane competitive Sus scrofa
4.2.1.3 2,2'-dipyridyl noncompetitive Bacillus subtilis
4.2.1.3 4-hydroxy-2-oxoglutarate competitive Sus scrofa
4.2.1.3 alpha-picolinic acid noncompetitive Bacillus subtilis
4.2.1.3 Fluorocitrate
-
 Bos taurus
4.2.1.3 Fluorocitrate linear competitive Rattus norvegicus
4.2.1.3 Fluorocitrate linear competitive Sus scrofa
4.2.1.3 oxaloacetate parabolic noncompetitive Sus scrofa
4.2.1.3 Oxalomalate competitive Rattus norvegicus
4.2.1.3 Oxalomalate competitive Saccharomyces cerevisiae
4.2.1.3 Oxalomalate competitive Solanum tuberosum
4.2.1.3 Oxalomalate competitive Sus scrofa
4.2.1.3 Phthalic acid competitive Sus scrofa
4.2.1.3 pyromellitic acid competitive Sus scrofa
4.2.1.3 Quinaldic acid noncompetitive Bacillus subtilis
4.2.1.3 threo-Ls-isocitrate competitive Bos taurus
4.2.1.3 trans-aconitate linear competitive Sus scrofa
4.2.1.3 tricarballylate linear competitive Bos taurus
4.2.1.3 tricarballylate
-
 Sus scrofa
4.2.1.3 trimellitic acid competitive Sus scrofa
4.2.1.3 trimesic acid competitive Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.3 additional information
-
 additional information
-
 Sus scrofa
4.2.1.3 additional information
-
 additional information
-
 Bos taurus
4.2.1.3 0.007
-
 cis-aconitate liver enzyme Bos taurus
4.2.1.3 0.009
-
 cis-aconitate
-
 Oryctolagus cuniculus
4.2.1.3 0.034
-
 isocitrate liver enzyme Bos taurus
4.2.1.3 0.099
-
 cis-aconitate heart enzyme Bos taurus
4.2.1.3 0.1
-
 cis-aconitate
-
 Sinapis alba
4.2.1.3 0.139
-
 isocitrate heart enzyme Bos taurus
4.2.1.3 0.15
-
 isocitrate
-
 Sinapis alba
4.2.1.3 0.2
-
 citrate liver enzyme Bos taurus
4.2.1.3 0.32
-
 isocitrate
-
 Oryctolagus cuniculus
4.2.1.3 0.58
-
 isocitrate
-
 Glycine max
4.2.1.3 0.9
-
 citrate
-
 Oryctolagus cuniculus
4.2.1.3 0.95
-
 citrate heart enzyme Bos taurus
4.2.1.3 1.7
-
 citrate
-
 Bacillus subtilis
4.2.1.3 4 4.4 citrate
-
 Sinapis alba

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.3 cytoplasm
-
 Rattus norvegicus 5737
-
4.2.1.3 mitochondrion
-
 Sus scrofa 5739
-
4.2.1.3 mitochondrion
-
 Bos taurus 5739
-
4.2.1.3 mitochondrion particulate-bound mitochondrial enzyme, the soluble mitochondrial enzyme is released from the mitochondria by freezing and thawing Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.3 89000
-
 equilibrium sedimentation Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.3 Aspergillus niger
-
-
-
4.2.1.3 Bacillus subtilis
-
-
-
4.2.1.3 Bos taurus
-
-
-
4.2.1.3 Glycine max
-
-
-
4.2.1.3 Oryctolagus cuniculus
-
-
-
4.2.1.3 Rattus norvegicus
-
 3 aconitases
-
4.2.1.3 Rheum sp.
-
 i.e. rhubarb
-
4.2.1.3 Saccharomyces cerevisiae
-
-
-
4.2.1.3 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.2.1.3 Sinapis alba
-
-
-
4.2.1.3 Solanum tuberosum
-
-
-
4.2.1.3 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.3
-
 Rattus norvegicus
4.2.1.3
-
 Sus scrofa
4.2.1.3
-
 Bos taurus
4.2.1.3
-
 Aspergillus niger
4.2.1.3
-
 Sinapis alba

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.3 heart
-
 Sus scrofa
-
4.2.1.3 heart
-
 Bos taurus
-
4.2.1.3 leaf
-
 Rheum sp.
-
4.2.1.3 liver
-
 Rattus norvegicus
-
4.2.1.3 liver
-
 Bos taurus
-
4.2.1.3 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.3 cis-aconitate + H2O
-
 Sus scrofa citrate
-
 r
4.2.1.3 cis-aconitate + H2O
-
 Bos taurus citrate
-
 r
4.2.1.3 cis-aconitate + H2O
-
 Oryctolagus cuniculus citrate
-
 r
4.2.1.3 cis-aconitate + H2O
-
 Sinapis alba citrate
-
 r
4.2.1.3 cis-aconitate + H2O
-
 Rattus norvegicus isocitrate
-
 ?
4.2.1.3 cis-aconitate + H2O
-
 Sus scrofa isocitrate
-
 r
4.2.1.3 cis-aconitate + H2O
-
 Bos taurus isocitrate
-
 r
4.2.1.3 citrate
-
 Bacillus subtilis cis-aconitate + H2O
-
 r
4.2.1.3 citrate
-
 Rattus norvegicus cis-aconitate + H2O
-
 ?
4.2.1.3 citrate
-
 Sus scrofa cis-aconitate + H2O
-
 r
4.2.1.3 citrate
-
 Bos taurus cis-aconitate + H2O
-
 r
4.2.1.3 citrate
-
 Oryctolagus cuniculus cis-aconitate + H2O
-
 r
4.2.1.3 citrate
-
 Sinapis alba cis-aconitate + H2O
-
 r
4.2.1.3 citrate
-
 Rattus norvegicus isocitrate
-
 ?
4.2.1.3 citrate
-
 Sus scrofa isocitrate
-
 r
4.2.1.3 citrate
-
 Bos taurus isocitrate
-
 r
4.2.1.3 isocitrate
-
 Rattus norvegicus citrate
-
 ?
4.2.1.3 isocitrate
-
 Sus scrofa citrate
-
 r
4.2.1.3 isocitrate
-
 Bos taurus citrate
-
 r
4.2.1.3 isocitrate
-
 Sus scrofa cis-aconitate + H2O
-
 r
4.2.1.3 isocitrate
-
 Bos taurus cis-aconitate + H2O
-
 r
4.2.1.3 isocitrate
-
 Oryctolagus cuniculus cis-aconitate + H2O
-
 r
4.2.1.3 isocitrate
-
 Glycine max cis-aconitate + H2O
-
 r
4.2.1.3 isocitrate
-
 Sinapis alba cis-aconitate + H2O
-
 r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.3 additional information
-
 additional information
-
 Bacillus subtilis
4.2.1.3 additional information
-
 additional information
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.3 5.8
-
 mitochondrial isoenzyme Rattus norvegicus
4.2.1.3 7.2
-
 phosphate buffer Rheum sp.
4.2.1.3 7.3
-
 soluble enzyme Rattus norvegicus
4.2.1.3 7.5
-
 glycerophosphate buffer Sus scrofa
4.2.1.3 7.7
-
 phosphate buffer Sus scrofa
4.2.1.3 8 8.5
-
 Sinapis alba
4.2.1.3 8.1
-
 N-ethylmorpholine buffer Sus scrofa
4.2.1.3 8.6
-
 veronal acetate buffer Sus scrofa