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Literature summary extracted from

  • Jiang, L.L.; Kobayashi, A.; Matsuura, H.; Fukushima, H.; Hashimoto, T.
    Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase (1996), J. Biochem., 120, 624-632.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.119 0.005
-
 dodec-2-enoyl-CoA
-
 Homo sapiens
4.2.1.119 0.005
-
 tetradec-2-enoyl-CoA
-
 Homo sapiens
4.2.1.119 0.007
-
 dec-2-enoyl-CoA
-
 Homo sapiens
4.2.1.119 0.009
-
 oct-2-enoyl-CoA
-
 Homo sapiens
4.2.1.119 0.015
-
 hex-2-enoyl-CoA
-
 Homo sapiens
4.2.1.119 0.03
-
 crotonyl-CoA
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.119 peroxisome
-
 Homo sapiens 5777
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.119 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.119
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.119 skin fibroblast
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
4.2.1.119 -20°C, stable for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.119 (R)-3-hydroxyoctanoyl-CoA no activity with (S)-3-hydroxyoctanoyl-CoA Homo sapiens octenoyl-CoA + H2O
-
 r
4.2.1.119 crotonyl-CoA + H2O very low activity with crotonyl-CoA Homo sapiens (R)-3-hydroxybutanoyl-CoA
-
 r
4.2.1.119 dec-2-enoyl-CoA + H2O 9-12% of the activity with hexenoyl-CoA, depending on preparation Homo sapiens (R)-3-hydroxydecanoyl-CoA
-
 ?
4.2.1.119 dodec-2-enoyl-CoA + H2O 4-5% of the activity with hexenoyl-CoA, depending on preparation Homo sapiens (R)-3-hydroxydodecanoyl-CoA
-
 ?
4.2.1.119 hex-2-enoyl-CoA + H2O
-
 Homo sapiens (R)-3-hydroxyhexanoyl-CoA
-
 r
4.2.1.119 additional information no activity with (S)-3-hydroxyoctanoyl-CoA Homo sapiens ?
-
 ?
4.2.1.119 oct-2-enoyl-CoA + H2O 30-40% of the activity with hexenoyl-CoA, depending on preparation Homo sapiens (R)-3-hydroxyoctanoyl-CoA
-
 r
4.2.1.119 tetradec-2-enoyl-CoA + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.119 D-3-hydroxyacyl-CoA dehydratase
-
 Homo sapiens