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Literature summary extracted from

  • Sumegi, B.; Srere, P.A.
    Binding of the enzymes of fatty acid beta-oxidation and some related enzymes to pig heart inner mitochondrial membrane (1984), J. Biol. Chem., 259, 8748-8752.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.35 mitochondrion
-
 Sus scrofa 5739
-
2.3.1.16 mitochondrial membrane
-
 Sus scrofa 31966
-
2.3.1.16 mitochondrion binding to inner membrane Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+ Sus scrofa
-
 acetoacetyl-CoA + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Sus scrofa
-
-
-
2.3.1.16 Sus scrofa
-
-
-
4.2.1.17 Sus scrofa
-
 The classification is ambiguous because the stereochemistry of the reaction product is not exactly determined
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 heart
-
 Sus scrofa
-
2.3.1.16 heart
-
 Sus scrofa
-
4.2.1.17 heart
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.35 0.75
-
 72% activivty is bound to the matrix surface of the inner mitochondria membrane, binding is inhibited by increasing ionic strength and pH Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+
-
 Sus scrofa acetoacetyl-CoA + NADH
-
 r
2.3.1.16 CoA + 3-oxoacyl-CoA
-
 Sus scrofa acyl-CoA + acetyl-CoA
-
 ?
4.2.1.17 crotonyl-CoA + H2O the classification is ambiguous because the stereochemistry is not exactly determined, The binding shows a moderate dependence on ionic strength (2-200 mM) and pH (6.5-8) Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.17 crotonase the classification is ambiguous because the stereochemistry of the reaction product is not exactly determined Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Sus scrofa