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Literature summary extracted from

  • Kwak, J.H.; Hong, K.W.; Lee, S.H.; Hong, J.H.; Lee, S.Y.
    Identification of amino acid residues involved in feedback inhibition of the anthranilate synthase in Escherichia coli (1999), J. Biochem. Mol. Biol., 32, 20-24.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.27 mutant anthanilate synthase Pro21Ser that is insensitive to feedback inhibition by Trp Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
4.1.3.27 P21S insensitive to feedback inhibition by Trp Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 L-Trp strain with a anthanilate synthase that is insensitive to feedback inhibition by Trp, the 61st nucleotide, C to A substitution, that changes Pro21 to Ser is the cause of the desensitization to feedback inhibition by Trp Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.27 additional information Escherichia coli first enzyme in the branch pathway in Trp biosynthesis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.27 Corynebacterium glutamicum
-
-
-
4.1.3.27 Escherichia coli
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strain with a mutant anthranilate synthase Pro21Gln that is insensitive to feedback inhibition by Trp
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.27 chorismate + L-Gln
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Escherichia coli anthranilate + pyruvate + L-glutamate
-
?
4.1.3.27 chorismate + L-Gln
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Corynebacterium glutamicum anthranilate + pyruvate + L-glutamate
-
?
4.1.3.27 additional information first enzyme in the branch pathway in Trp biosynthesis Escherichia coli ?
-
?