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Literature summary extracted from

  • Zalkin, H.; Kling, D.
    Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium (1968), Biochemistry, 7, 3566-3573.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 2-oxoglutarate reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Bromopyruvate inactivation prevented by chorismate and Trp Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Diethylamine reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Dimethylamine reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Gln reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Glu reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 L-Trp competitive with chorismate, noncompetitive with NH4+, reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 methylamine reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 N-Methylhydroxylamine reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 NEM reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 PCMB reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 pyruvate competitive with respect to chorismate, noncompetitive with respect to NH4+, reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 trimethylamine reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.27 0.11
-
chorismate reaction of component I, with NH4+ as cosubstrate Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 24
-
NH4+ reaction of component I Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.27 Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium
4.1.3.27 Mg2+ reaction of component I with NH4+ as substrate Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.27 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.27 component I Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.3.27 0.384
-
activity of component I Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.27 chorismate + L-Gln component I is inactive with L-Gln Salmonella enterica subsp. enterica serovar Typhimurium anthranilate + pyruvate + L-glutamate
-
?
4.1.3.27 chorismate + NH4+ reaction is catalyzed by component I alone and in combination with component II Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?

Subunits

EC Number Subunits Comment Organism
4.1.3.27 More component I has a MW of 63000 Da, gel filtration Salmonella enterica subsp. enterica serovar Typhimurium