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Literature summary extracted from
- Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis (1974), J. Biol. Chem., 249, 5208-5212.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.3.24 | acetyl-CoA | in direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA | Pseudomonas sp. |  |
| 4.1.3.24 | glycolate | in direction of malyl-CoA synthesis: competitive with respect to glyoxylate and noncompetitive with respect to acetyl-CoA.In direction of malyl-CoA cleavage: competitive with respect to malyl-CoA | Pseudomonas sp. | |
| 4.1.3.24 | oxalate | in direction of malyl-CoA synthesis: competitive with respect to glyoxylate and noncompetitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: competitive with respect to malyl-CoA | Pseudomonas sp. | |
| 4.1.3.24 | oxylate | in direction of malyl-CoA cleavage: competitive with respect to malyl-CoA | Pseudomonas sp. | |
| 4.1.3.24 | propionyl-CoA | in direction of malyl-CoA synthesis: uncompetitive with respect to glyoxylate and competitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA | Pseudomonas sp. | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.24 | Pseudomonas sp. | - |
Shaw strain MA | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.3.24 | - |
Pseudomonas sp. |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.1.3.24 | (S)-malyl-CoA = acetyl-CoA + glyoxylate | in the reverse direction ordered sequential mechanism with glyoxylate binding prior to acetyl-CoA | Pseudomonas sp. |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.24 | additional information | - |
- |
Pseudomonas sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.24 | (3S)-3-carboxy-3-hydroxypropanoyl-CoA | - |
Pseudomonas sp. | acetyl-CoA + glyoxylate | - |
r | |
| 4.1.3.24 | acetyl-CoA + glyoxylate | - |
Pseudomonas sp. | (3S)-3-carboxy-3-hydroxypropanoyl-CoA | - |
r | |
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