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Literature summary extracted from
- Purification and partial characterization of the phosphoglucomutase isozymes from human placenta (1990), Prep. Biochem., 20, 219-240.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.2.2 | alpha-D-glucose 1,6-diphosphate | Km: 0.00077-0.00163 mM | Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.2.2 | 2,3-bisphosphoglycerate | - |
Homo sapiens | |
| 5.4.2.2 | fructose 1,6-diphosphate | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.2.2 | 0.057 | 0.062 | alpha-D-glucose 1-phosphate | isozyme PGM2 | Homo sapiens | |
| 5.4.2.2 | 0.0805 | 0.088 | alpha-D-glucose 1-phosphate | isozyme PGM1 | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.2.2 | Mg2+ | Km: 0.016-0.020 mM | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.2 | 58500 | - |
isozyme PGM1, gel filtration, SDS-PAGE | Homo sapiens |
| 5.4.2.2 | 69000 | - |
isozyme PGM2, gel filtration, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.2.2 | Homo sapiens | - |
human | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.4.2.2 | isozymes PGM1 and PGM2 | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.4.2.2 | placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.2 | 40.2 | - |
isozyme PGM2, substrate glucose 1-phosphate | Homo sapiens |
| 5.4.2.2 | 1442 | - |
isozyme PGM1, substrate glucose 1-phosphate | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.2.2 | alpha-D-glucose 1-phosphate | - |
Homo sapiens | alpha-D-glucose 6-phosphate | - |
? | |
| 5.4.2.2 | alpha-D-glucose 1-phosphate | - |
Homo sapiens | D-glucose 6-phosphate | - |
? | |
| 5.4.2.2 | additional information | isozyme PGM2 also displays activities of phosphoribomutase and glucose 1,6-bisphosphate synthase | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.4.2.2 | monomer | 1 * 69000, isozyme PGM1, SDS-PAGE | Homo sapiens |
| 5.4.2.2 | monomer | 1 * 58500, isozyme PGM1, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.2 | 52 | - |
isozyme PGM1, 10 min, 80% loss of activity | Homo sapiens |
| 5.4.2.2 | 52 | - |
isozyme PGM2, 10 min, 50% loss of activity | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.2 | 8 | - |
isozymes PGM1 and PGM2 | Homo sapiens |
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Release 2023.1 (January 2023)
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