EC Number | General Stability | Organism |
---|---|---|
3.2.2.6 | 50% inactivation at 2 M urea | Homo sapiens |
3.2.2.6 | SDS, even at micromolar concentration, leads to complete inactivation of the enzyme | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.2.2.6 | Ag+ | 50% inhibition of NADase and 300% activation of adenosine diphosphate cyclase; at 2 mM 50% inhibition of NADase activity and 300% activation of cADPR activity | Homo sapiens | |
3.2.2.6 | Cr3+ | inhibition of NADase and adenosine diphosphate cyclase | Homo sapiens | |
3.2.2.6 | Hg2+ | complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase | Homo sapiens | |
3.2.2.6 | Pb2+ | complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase | Homo sapiens | |
3.2.2.6 | SDS | - |
Homo sapiens | |
3.2.2.6 | Sn2+ | complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase | Homo sapiens | |
3.2.2.6 | Zn2+ | inhibition of NADase and adenosine diphosphate cyclase | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.6 | 0.026 | - |
NAD+ | - |
Homo sapiens | |
3.2.2.6 | 0.026 | - |
NAD+ | pH 7.0, 28°C | Homo sapiens | |
3.2.2.6 | 0.033 | - |
epsilonNAD+ | - |
Homo sapiens | |
3.2.2.6 | 0.033 | - |
nicotinamide 1,N6-ethenoadenine dinucleotide | pH 7.0, 28°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.2.2.6 | membrane | - |
Homo sapiens | 16020 | - |
3.2.2.6 | microsome | - |
Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.2.2.6 | Ag+ | 50% inhibition of NADase and 300% activation of adenosine diphosphate cyclase | Homo sapiens | |
3.2.2.6 | Ag+ | at 2 mM 50% inhibition of NADase activity and 300% activation of ADPR activity | Homo sapiens | |
3.2.2.6 | Cu2+ | stimulation of cADPR activity | Homo sapiens | |
3.2.2.6 | additional information | no effects by K+, Cd2+, Fe2+, Fe3+, and Mn2+ | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | additional information | - |
native enzyme shows high molecular weight and elutes in the void volumes from a Superose 12 gel filtration column | Homo sapiens |
3.2.2.6 | 45000 | - |
- |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.2.6 | additional information | Homo sapiens | enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.2.6 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.2.2.6 | partial | Homo sapiens |
3.2.2.6 | partially from spleen microsomal membranes after solubilization with Triton X-100, chromatography methods, 133fold | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.2.2.6 | NAD+ + H2O = ADP-D-ribose + nicotinamide + H+ | also catalyses transfer of ADP-ribose(P) residues | Homo sapiens |
EC Number | Renatured (Comment) | Organism |
---|---|---|
3.2.2.6 | 80% renaturation of urea and SDS denatured enzyme by treatment with Triton X-100 in a 20:1 v/w ratio with SDS | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.2.2.6 | spleen | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 0.02 | - |
partially purified enzyme, ADPR activity | Homo sapiens |
3.2.2.6 | 0.113 | - |
partially purified enzyme, cADPR activity | Homo sapiens |
3.2.2.6 | 2.205 | - |
partially purified enzyme, NADase activity | Homo sapiens |
EC Number | Storage Stability | Organism |
---|---|---|
3.2.2.6 | 20°C, lyophilized enzyme, 90% remaining activity after 6 months | Homo sapiens |
3.2.2.6 | 4°C to -196°C, 10 mM Tris-HCl, pH 8.0, 0.1% Triton X-100, at least 1 month, stable | Homo sapiens |
3.2.2.6 | 4°C, -20°C, -80°C or -196°C, pH 8.0, 0.1% Triton X-100, 10 mM Tris-HCl, stable for at least 1 month | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.2.6 | 3-acetylpyridine + adenosine diphosphoribose | transglycosylation activity, very poor hydrolytic activity with this substrate | Homo sapiens | 3-acetylpyridine adenine dinucleotide + phosphate | - |
? | |
3.2.2.6 | 3-acetylpyridine adenine dinucleotide + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | 3-acetylpyridine hypoxanthine dinucleotide + H2O | low activity | Homo sapiens | ? | - |
? | |
3.2.2.6 | 3-pyridine adenine dinucleotide + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | 3-pyridinealdehyde hypoxanthine dinucleotide + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | 3-pyridinealdehyde hypoxanthine dinucleotide + H2O | 60% activity compared to the activity with NAD+ | Homo sapiens | ? | - |
? | |
3.2.2.6 | cyclic ADP-ribose + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | cyclic ADP-ribose + H2O | i.e. ADPR activity | Homo sapiens | adenosine diphosphoribose + ? | - |
? | |
3.2.2.6 | epsilon-NAD+ + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | epsilon-NADP+ + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | additional information | enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose | Homo sapiens | ? | - |
? | |
3.2.2.6 | additional information | enzyme is multicatalytic, it also catalyzes the synthesis of cyclic ADP-ribose from NAD+ and the hydrolysis to adenosine diphosphoribose | Homo sapiens | ? | - |
? | |
3.2.2.6 | NAD+ | - |
Homo sapiens | cyclic ADP-ribose + nicotinamide | - |
? | |
3.2.2.6 | NAD+ + ? | i.e. cADPR activity | Homo sapiens | cyclic ADP-ribose + ? | - |
? | |
3.2.2.6 | NAD+ + H2O | - |
Homo sapiens | ADP-ribose + nicotinamide | - |
? | |
3.2.2.6 | NADP+ + H2O | - |
Homo sapiens | nicotinamide + ADPribose-phosphate | - |
? | |
3.2.2.6 | NADP+ + H2O | 80% activity compared to the activity with NAD+ | Homo sapiens | ADP-ribose-P + nicotinamide | - |
? | |
3.2.2.6 | NGD+ + H2O | as effective as substrate as NAD+ | Homo sapiens | GDP-ribose + nicotinamide | - |
? | |
3.2.2.6 | nicotinamide 1,N6-ethenoadenine dinucleotide + H2O | i.e. epsilonNAD+, used for a fluorometric assay | Homo sapiens | ? | - |
? | |
3.2.2.6 | nicotinamide guanine dinucleotide + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | nicotinamide-hypoxanthine dinucleotide + H2O | - |
Homo sapiens | ? | - |
? | |
3.2.2.6 | thio-NAD+ + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.2.2.6 | oligomer | x * 45000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.2.6 | NAD(P)+-glycohydrolase | - |
Homo sapiens |
3.2.2.6 | NADase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 38 | - |
- |
Homo sapiens |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 38 | 50 | inactive above 50°C | Homo sapiens |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 38 | - |
half-life: about 1 day | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 7 | - |
- |
Homo sapiens |
3.2.2.6 | 7 | - |
NADase activity | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.2.2.6 | 4.5 | 9.5 | - |
Homo sapiens |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
3.2.2.6 | Homo sapiens | isoelectric focusing | - |
4.9 |