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Literature summary extracted from

  • Diczfalusy, U.; Falardeau, P.; Hammarström, S.
    Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase (1977), FEBS Lett., 84, 271-274.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 2-Isopropyl-3-nicotinylindole
-
 Homo sapiens
5.3.99.5 4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
-
 Homo sapiens
5.3.99.5 9alpha,11alpha-Azo-15-(S)Hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
 Homo sapiens
5.3.99.5 9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
-
 Homo sapiens
5.3.99.5 imidazole
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.5 additional information Homo sapiens production of thromboxane A2, an unstable bioregulator that induces platelet release reaction, platelet aggregation and smooth muscle contraction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 additional information production of thromboxane A2, an unstable bioregulator that induces platelet release reaction, platelet aggregation and smooth muscle contraction Homo sapiens ?
-
 ?
5.3.99.5 prostaglandin H1
-
 Homo sapiens 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
 ?