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Literature summary extracted from

  • Brömme, D.; Okamoto, K.; Wang, B.B.; Biroc, S.
    Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts (1996), J. Biol. Chem., 271, 2126-2132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 Benzyloxycarbonyl-Phe-Ala-CHN2
-
 Homo sapiens
3.4.22.38 Benzyloxycarbonyl-Phe-Phe-CHN2
-
 Homo sapiens
3.4.22.38 calpeptin
-
 Homo sapiens
3.4.22.38 chicken cystatin
-
 Homo sapiens
3.4.22.38 chymostatin
-
 Homo sapiens
3.4.22.38 iodoacetate
-
 Homo sapiens
3.4.22.38 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.38 0.0004
-
 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.0038
-
 benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.0075
-
 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.0131
-
 Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.0185
-
 Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.023
-
 benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.38 29000
-
 mature cathepsin O2, SDS-PAGE Homo sapiens
3.4.22.38 43000
-
 precursor cathepsin O2, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Homo sapiens
-
 expressed in Sf9 cells with Autographa californica nuclear polyhedrosis virus
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.38 no glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.38 cathepsin O2 precursor, which can be processed to mature enzyme at 4 C Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 osteoclast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens Benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Collagen type I + H2O
-
 Homo sapiens Fragemnts of collagen type I cleavage in telopeptide region ?

Subunits

EC Number Subunits Comment Organism
3.4.22.38 monomer 1 * 43000, precursor cathepsin O2, SDS-PAGE Homo sapiens
3.4.22.38 monomer 1 * 29000, mature cathepsin O2, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.22.38 0.0005
-
 benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.01
-
 Benzyloxycarbonyl-Val-Val-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.02
-
 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.9
-
 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 0.98
-
 benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens
3.4.22.38 1.06
-
 Benzyloxycarbonyl-Val-Arg 4-methylcoumarin 7-amide
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.38 6 6.5
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.38 4 8 less than 50% of maximal activity above and below Homo sapiens