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Literature summary extracted from
- Pro-protein convertases of subtilisin/kexin family (1994), Methods Enzymol., 244, 175-188.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.93 | - |
Homo sapiens |
| 3.4.21.93 | - |
Mus musculus |
| 3.4.21.94 | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.94 | additional information | Homo sapiens | processing of precursors that are routed toward secretory granules | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B24 | Mammalia | - |
- |
- |
| 3.4.21.B24 | Rattus norvegicus | - |
- |
- |
| 3.4.21.93 | Homo sapiens | - |
- |
- |
| 3.4.21.93 | Mus musculus | - |
- |
- |
| 3.4.21.94 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.B24 | proteolytic modification | activation | Mammalia |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.93 | - |
Homo sapiens |
| 3.4.21.93 | - |
Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.B24 | germ cell | - |
Rattus norvegicus | - |
| 3.4.21.B24 | germ cell | - |
Mammalia | - |
| 3.4.21.B24 | ovary | - |
Mammalia | - |
| 3.4.21.B24 | spermatid | round spermatids | Rattus norvegicus | - |
| 3.4.21.B24 | spermatid | round spermatids, but not elongates ones | Mammalia | - |
| 3.4.21.B24 | spermatocyte | - |
Rattus norvegicus | - |
| 3.4.21.B24 | spermatocyte | - |
Mammalia | - |
| 3.4.21.B24 | testis | - |
Rattus norvegicus | - |
| 3.4.21.B24 | testis | - |
Mammalia | - |
| 3.4.21.94 | additional information | distribution in tissues | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B24 | additional information | cleaves fluorogenic peptide substrates at pairs of basic residues | Mammalia | ? | - |
? | |
| 3.4.21.B24 | additional information | cleaves fluorogenic peptide substrates at pairs of basic residues | Rattus norvegicus | ? | - |
? | |
| 3.4.21.93 | additional information | unlike prohormone convertase 2, does not hydrolyze proluteinizing-hormone-releasing-hormone | Mus musculus | ? | - |
? | |
| 3.4.21.93 | additional information | unlike prohormone convertase 2, does not hydrolyze proluteinizing-hormone-releasing-hormone | Homo sapiens | ? | - |
? | |
| 3.4.21.93 | additional information | cleaves precursors both at specific single and pairs of basic residues | Mus musculus | ? | - |
? | |
| 3.4.21.93 | additional information | cleaves precursors both at specific single and pairs of basic residues | Homo sapiens | ? | - |
? | |
| 3.4.21.93 | Pro-opiomelanocortin + H2O | - |
Mus musculus | Adrenocorticotropic hormone + beta-lipotropin + beta endorphin | - |
? | |
| 3.4.21.93 | Pro-opiomelanocortin + H2O | - |
Homo sapiens | Adrenocorticotropic hormone + beta-lipotropin + beta endorphin | - |
? | |
| 3.4.21.93 | prodynorphin + H2O | hydrolyzes peptide bonds with Tyr at position P2 | Mus musculus | dynorphin + ? | - |
? | |
| 3.4.21.93 | prodynorphin + H2O | hydrolyzes peptide bonds with Tyr at position P2 | Homo sapiens | dynorphin + ? | - |
? | |
| 3.4.21.93 | Proenkephalin + H2O | - |
Mus musculus | Enkephalin + ? | - |
? | |
| 3.4.21.93 | Proenkephalin + H2O | - |
Homo sapiens | Enkephalin + ? | - |
? | |
| 3.4.21.93 | Proinsulin + H2O | - |
Mus musculus | Insulin + ? | - |
? | |
| 3.4.21.93 | Proinsulin + H2O | - |
Homo sapiens | Insulin + ? | - |
? | |
| 3.4.21.93 | Prorenin + H2O | - |
Mus musculus | Renin + ? | - |
? | |
| 3.4.21.93 | Prorenin + H2O | - |
Homo sapiens | Renin + ? | - |
? | |
| 3.4.21.93 | Prosomatostatin + H2O | - |
Mus musculus | Somatostatin + ? | - |
? | |
| 3.4.21.93 | Prosomatostatin + H2O | - |
Homo sapiens | Somatostatin + ? | - |
? | |
| 3.4.21.94 | additional information | cleavage specificity, cleaves precursors both at specific single and pairs of basic residues, not: prorenin, prosomatostatin | Homo sapiens | ? | - |
? | |
| 3.4.21.94 | additional information | processing of precursors that are routed toward secretory granules | Homo sapiens | ? | - |
? | |
| 3.4.21.94 | Pro-opiomelanocortin + H2O | from mouse and pig | Homo sapiens | Opiomelanocortin + ? | - |
? | |
| 3.4.21.94 | prodynorphin + H2O | rat | Homo sapiens | dynorphin + ? | - |
? | |
| 3.4.21.94 | prodynorphin + H2O | cleavage at a single Arg residue | Homo sapiens | dynorphin + ? | - |
? | |
| 3.4.21.94 | prodynorphin + H2O | at a bond in which P2 is Thr | Homo sapiens | dynorphin + ? | - |
? | |
| 3.4.21.94 | Proenkephalin + H2O | human | Homo sapiens | Enkephalin + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.B24 | PC4 | - |
Rattus norvegicus |
| 3.4.21.B24 | PC4 | - |
Mammalia |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.93 | 5.5 | 6 | - |
Mus musculus |
| 3.4.21.93 | 5.5 | 6 | - |
Homo sapiens |
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