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Literature summary extracted from

  • Kräusslich, H.G.; Wimmer, E.
    Viral proteinases (1988), Annu. Rev. Biochem., 57, 701-754.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.28
-
 Foot-and-mouth disease virus
3.4.22.28
-
 Enterovirus C

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.28 iodoacetamide
-
 coxsackievirus
3.4.22.28 iodoacetamide
-
 echovirus
3.4.22.28 iodoacetamide
-
 Encephalomyocarditis virus
3.4.22.28 iodoacetamide
-
 enterovirus
3.4.22.28 iodoacetamide
-
 Enterovirus C
3.4.22.28 iodoacetamide
-
 Enterovirus E
3.4.22.28 iodoacetamide
-
 Foot-and-mouth disease virus
3.4.22.28 iodoacetamide
-
 Hepatovirus A
3.4.22.28 iodoacetamide
-
 picornaviridae
3.4.22.28 NEM
-
 coxsackievirus
3.4.22.28 NEM
-
 echovirus
3.4.22.28 NEM
-
 Encephalomyocarditis virus
3.4.22.28 NEM
-
 enterovirus
3.4.22.28 NEM
-
 Enterovirus C
3.4.22.28 NEM
-
 Enterovirus E
3.4.22.28 NEM
-
 Foot-and-mouth disease virus
3.4.22.28 NEM
-
 Hepatovirus A
3.4.22.28 NEM
-
 picornaviridae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.28 picornavirus polyprotein + H2O Foot-and-mouth disease virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O Enterovirus C involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O Encephalomyocarditis virus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O enterovirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O Hepatovirus A involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O coxsackievirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O Enterovirus E involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O echovirus involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O picornaviridae involved in proteolytic processing of virus polyprotein hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O Enterovirus C turns off host-cell protein synthesis ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O enterovirus turns off host-cell protein synthesis ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O Hepatovirus A turns off host-cell protein synthesis ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O coxsackievirus turns off host-cell protein synthesis ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O picornaviridae turns off host-cell protein synthesis ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O Human rhinovirus sp. turns off host-cell protein synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.90 Sindbis virus
-
-
-
3.4.22.28 coxsackievirus
-
-
-
3.4.22.28 echovirus
-
-
-
3.4.22.28 Encephalomyocarditis virus
-
-
-
3.4.22.28 enterovirus
-
 human rhinovirus
-
3.4.22.28 Enterovirus C
-
-
-
3.4.22.28 Enterovirus E
-
-
-
3.4.22.28 Foot-and-mouth disease virus
-
-
-
3.4.22.28 Hepatovirus A
-
-
-
3.4.22.28 picornaviridae
-
 overview
-
3.4.22.29 coxsackievirus
-
-
-
3.4.22.29 enterovirus
-
 bovine enterovirus
-
3.4.22.29 Enterovirus C
-
 type 1 (Mahoney strain)
-
3.4.22.29 Hepatovirus A
-
-
-
3.4.22.29 Human rhinovirus sp.
-
-
-
3.4.22.29 picornaviridae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.29 from infected HeLa cells Enterovirus C

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.90 Sindbis virus core protein + H2O
-
 Sindbis virus Hydrolyzed Sindbis core protein
-
 ?
3.4.22.28 dansyl-Glu-Glu-Glu-Ala-Met-Glu-Gly-Ile-Thr-Asn-Lys-NH2 + H2O i.e. peptide corresponding to cleavage site between poliovirus polypeptides 2A and 2B Enterovirus C dansyl-Glu-Glu-Glu-Ala-Met-Glu + Gly-Ile-Thr-Asn-Lys-NH2
-
 ?
3.4.22.28 L-P1-2A precursor polypeptide of encephalomyocarditis virus + H2O cardioviruses Encephalomyocarditis virus peptide P1-2A
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection Foot-and-mouth disease virus ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection Enterovirus C ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection Encephalomyocarditis virus ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection enterovirus ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection Hepatovirus A ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection coxsackievirus ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection Enterovirus E ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection echovirus ?
-
 ?
3.4.22.28 additional information no hydrolysis of cellular proteins during viral infection picornaviridae ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication Foot-and-mouth disease virus ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication Enterovirus C ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication Encephalomyocarditis virus ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication enterovirus ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication Hepatovirus A ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication coxsackievirus ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication Enterovirus E ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication echovirus ?
-
 ?
3.4.22.28 additional information no maturation cleavage in picornavirus replication picornaviridae ?
-
 ?
3.4.22.28 P1-2A precursor polypeptide of encephalomyocarditis virus + H2O cardio- and aphthoviruses Encephalomyocarditis virus peptide P1 + peptide 2A
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus Foot-and-mouth disease virus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus Encephalomyocarditis virus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus enterovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus coxsackievirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus Enterovirus E hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus echovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus picornaviridae hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Foot-and-mouth disease virus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Encephalomyocarditis virus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein enterovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein coxsackievirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein Enterovirus E hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein echovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 picornavirus polyprotein + H2O involved in proteolytic processing of virus polyprotein picornaviridae hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.28 poliovirus P1 precursor polyprotein + H2O
-
 Enterovirus C capsid proteins
-
 ?
3.4.22.28 poliovirus polyprotein + H2O exclusive cleavage site: Gln-Gly Enterovirus C hydrolyzed poliovirus polyprotein
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis Enterovirus C ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis enterovirus ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis Hepatovirus A ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis coxsackievirus ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis picornaviridae ?
-
 ?
3.4.22.29 eukaryotic translation initiation factor 4F p220 subunit + H2O turns off host-cell protein synthesis Human rhinovirus sp. ?
-
 ?
3.4.22.29 additional information cleavage specificity Enterovirus C ?
-
 ?
3.4.22.29 additional information cleavage specificity enterovirus ?
-
 ?
3.4.22.29 additional information cleavage specificity Hepatovirus A ?
-
 ?
3.4.22.29 additional information cleavage specificity coxsackievirus ?
-
 ?
3.4.22.29 additional information cleavage specificity picornaviridae ?
-
 ?
3.4.22.29 additional information cleavage specificity Human rhinovirus sp. ?
-
 ?
3.4.22.29 additional information the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) Enterovirus C ?
-
 ?
3.4.22.29 additional information the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) enterovirus ?
-
 ?
3.4.22.29 additional information the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) coxsackievirus ?
-
 ?
3.4.22.29 additional information the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) picornaviridae ?
-
 ?
3.4.22.29 additional information the primary cleavage in cardio- and aphthovirus occurs between 2A and 2B (cleavage site: Gly-Pro in-Asn-Pro-Gly-Pro-) Human rhinovirus sp. ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein Enterovirus C ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein enterovirus ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein Hepatovirus A ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein coxsackievirus ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein picornaviridae ?
-
 ?
3.4.22.29 additional information enzyme is active both as structural element of a precursor and as mature protein Human rhinovirus sp. ?
-
 ?
3.4.22.29 P1/P2 precursor polypeptide + H2O from poliovirus Enterovirus C poliovirus 1C'D polypeptide + proteinase 2Apro
-
 ?
3.4.22.29 P1/P2 precursor polypeptide + H2O from poliovirus Human rhinovirus sp. poliovirus 1C'D polypeptide + proteinase 2Apro
-
 ?
3.4.22.29 P1/P2 precursor polypeptide + H2O from rhinovirus, cleaves P1/P2 junction Enterovirus C poliovirus 1C'D polypeptide + proteinase 2Apro
-
 ?
3.4.22.29 P1/P2 precursor polypeptide + H2O from rhinovirus, cleaves P1/P2 junction Human rhinovirus sp. poliovirus 1C'D polypeptide + proteinase 2Apro
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly enterovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly coxsackievirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly picornaviridae hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O immediately after protease 2A has been synthesized the Tyr-Gly pair between P1 and P2 of the nascent rhinovirus or enterovirus chain is cleaved intramolecularly Human rhinovirus sp. hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' enterovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' coxsackievirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' picornaviridae hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves intermolecularly at a second site in the 3D protein between 3C' and 3D' Human rhinovirus sp. hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins Enterovirus C hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins enterovirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins Hepatovirus A hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins coxsackievirus hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins picornaviridae hydrolyzed picornavirus polyprotein
-
 ?
3.4.22.29 picornavirus polyprotein + H2O cleaves Tyr-Gly pairs in both Thr-Tyr-Gly sequences of poliovirus polyprotein, cleaves Thr-Gly in Thr-Thr-Gly (serotype B1) or Asn-Thr-Gly (serotype B3) of coxsackievirus polyprotein, cleaves Ala-Gly in Thr-Ala-Gly (HRV 2), Tyr-Gly in Ser-Tyr-Gly (HRV 14) and Val-Gly in Asn-Val-Gly (HRV 89) in rhinovirus polyproteins Human rhinovirus sp. hydrolyzed picornavirus polyprotein
-
 ?