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Literature summary extracted from

  • Dalbey, R.E.; von Heijne, G.
    Signal peptidases in prokaryotes and eukaryotes--a new protease family [published erratum appears in Trends Biochem Sci 1993 Jan;18(1):25] (1992), Trends Biochem. Sci., 17, 474-478.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.89 19 kDa subunit encoded by SEC11 gene Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.89 additional information not inhibited by classical protease inhibitors such as phenylmethyl sulfonyl fluoride, tosyl-amido-2-phenylethylchloromethylketone, EDTA, o-phenanthroline, N-ethylmaleimide, dinitrophenol, carboxyphenanthroline, or 2,6-pyridinecarboxylic acid Escherichia coli
3.4.21.89 Signal peptides that include a Pro residue at position +1
-
Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.89 cytoplasm integral component of the cytoplasmic membrane Escherichia coli 5737
-
3.4.21.89 membrane integral membrane protein Gallus gallus 16020
-
3.4.21.89 membrane integral membrane protein Escherichia coli 16020
-
3.4.21.89 membrane integral membrane protein Saccharomyces cerevisiae 16020
-
3.4.21.89 mitochondrion inner membrane Saccharomyces cerevisiae 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.89 32000
-
active monomer, SDS-PAGE Pseudomonas fluorescens
3.4.21.89 36000
-
active monomer, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
3.4.21.89 37000
-
active monomer, SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.89 signal peptides from preproteins + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
mature proteins
-
?
3.4.21.89 signal peptides from preproteins + H2O Escherichia coli
-
mature proteins
-
?
3.4.21.89 signal peptides from preproteins + H2O Pseudomonas fluorescens
-
mature proteins
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.89 Escherichia coli
-
-
-
3.4.21.89 Gallus gallus
-
-
-
3.4.21.89 Pseudomonas fluorescens
-
-
-
3.4.21.89 Saccharomyces cerevisiae
-
-
-
3.4.21.89 Saccharomyces cerevisiae
-
yeast
-
3.4.21.89 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.89 Cleavage of hydrophobic, N-terminal signal or leader sequences mechanism Gallus gallus
3.4.21.89 Cleavage of hydrophobic, N-terminal signal or leader sequences mechanism Escherichia coli
3.4.21.89 Cleavage of hydrophobic, N-terminal signal or leader sequences mechanism Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.89 additional information specificity overview Gallus gallus ?
-
?
3.4.21.89 additional information specificity overview Escherichia coli ?
-
?
3.4.21.89 additional information specificity overview Saccharomyces cerevisiae ?
-
?
3.4.21.89 additional information cleavage of E. coli enzyme requires a small residue at-1 and a small or aliphatic residue at-3, presence of a helix breaker allows the pre-protein to bind with higher affinity, signal peptides that include a Pro residue at position-1 are not cleaved in E. coli Escherichia coli ?
-
?
3.4.21.89 signal peptides from preproteins + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium mature proteins
-
?
3.4.21.89 signal peptides from preproteins + H2O
-
Escherichia coli mature proteins
-
?
3.4.21.89 signal peptides from preproteins + H2O
-
Pseudomonas fluorescens mature proteins
-
?